Top 80+ Solved Drug Distribution MCQ Questions Answer
Q. Who has higher fat content?
a. Adults of age above 70
b. Adults of age more than 20
c. Infants and elders
d. Children at puberty
Q. Who has poorly developed BBB?
a. Infants
b. Adults Of age more than 20
c. Aged
d. Children at puberty
Q. During pregnancy, drug distribution is more. Which of the following sentences describe the given fact better?
a. The baby needs more drug
b. The mother needs more drug due to high metabolism
c. The surface area increases in the mother’s body due to the presence of uterus, placenta, and foetus. Thus more area for distribution of drugs
d. The growth of the uterus, placenta, and foetus increases the volume thus increasing distribution. And even the baby forms a separate compartment for a drug to get distributed
Q. What happens when an obese person is given with a lipophilic drug?
a. Drug aggregation will begin
b. He cannot absorb lipophilic drugs
c. High adipose tissue take up most of the lipophilic drug
d. A large amount of drug is needed as the person’s weight is more
Q. What is the consequence of diet high in fats?
a. The patient can’t be given with acidic drugs
b. The patient can’t be given with basic drugs
c. The basic drugs will aggregate and become poisonous for him
d. The high fatty acid level affect the binding of acidic drugs
Q. The extent to which a drug is distributed is a tissue depends upon ___________ and _____________
a. The concentration of a drug, tissue/blood partition coefficient of drug
b. Tissue volume, tissue/blood partition coefficient of drug
c. Tissue surface area, tissue/blood partition coefficient of drug
d. Blood density upon the tissue, tissue/blood partition coefficient of drug
Q. Which one of the following has a high perfusion rate?
a. Fat
b. Muscle and skin
c. Lungs and kidney
d. Bone
Q. Which one of the following has very low perfusion rate?
a. Fat and bone
b. Muscle and skin
c. Lungs and kidney
d. Liver and Heart
Q. Disease state of a patient can influence drug distribution across the body.
a. True
b. False
c. none
d. all
Q. In meningitis and encephalitis polar antibiotics gain access to BBB which don’t happen to a healthyperson.
a. True
b. False
c. none
d. all
Q. What reasons make tissue-drug binding important for drug distribution?
a. Increases the volume of distribution of drugs and results in localization of drug at a specific site
b. Increases the volume of distribution of drugs
c. Results in localization of drugs at a tissue specific site
d. Increases in absorption from the tissue due to concentration increasing
Q. Following is the order in decreasing order of drug binding to the extravascular tissue. Which one isthe correct order?
a. Liver > kidney > muscle > lung
b. Liver > muscle > lung > kidney
c. Liver > muscle > kidney > lung
d. Liver > kidney > lung > muscle
Q. What is the relation between halogenated hydrocarbon and liver?
a. Halogenated hydrocarbon is a drug for liver problems
b. Halogenated hydrocarbon is nutrition for liver
c. Halogenated hydrocarbon causes hepatotoxicity
d. Halogenated hydrocarbon forms the bile juices in liver
Q. Which drugs accumulate in liver?
a. Acidic drugs like imipramine
b. Basic drugs like imipramine
c. Halogenated hydrocarbons
d. Chloroquinine