Top 80+ Solved Bioavailability and Bioequivalence MCQ Questions Answer
Q. According to Biopharmaceutics Classification System (BCS), Class II drugs have
a. High solubility/High permeability
b. Low solubility /High permeability
c. High solubility /Low permeability
d. Low solubility /Low permeability
Q. ………………is the ratio of the mean residence time to the absorption time
a. Absorption number
b. Dissolution number
c. Dose number
d. Intrinsic dissolution
Q. In vitro dissolution rate studies on drug product are useful in bioavailability evaluation if they are correlated with
a. Disintegration rate
b. In vivo studies in at least 3 species of animals
c. Chemical stability of drugs
d. In vivo studies in human
Q. The gold coating on a USP Dissolution apparatus - I basket should be:
a. Not more than 2.5 m in thickness
b. Not more than 0.1 mm in thickness
c. Not more than 0.025 m in thickness
d. Not more than 0.22 mm in thickness
Q. Which of the following is initial step for drug absorption in case of tablet dosage form?
a. Friability
b. Disintegration
c. Dissolution
d. None of these
Q. Under the concept biopharmaceutics, hydrophobic drugs are
a. Permeation rate limited
b. Dissolution rate limited
c. Both
d. Initially permeation then dissolution rate limited
Q. Which of the following methods are used to determine Area Under curve?
a. Cut and weigh method
b. Trapezoidal method
c. Integration method
d. All of the above
Q. Apparatus 5 of dissolution apparatus is known as
a. Paddle over disk
b. Flow-through- cell
c. Reciprocating disk
d. Basket
Q. Bioavailability differences among oral formulations of a drug are most likely to occur if the drug
a. Is freely water soluble
b. Is completely absorbed
c. Is incompletely absorbed
d. Undergoes little first-pass metabolism
Q. Bioavailability is expressed by formula
a. AUC IV / AUC oral
b. AUC ora1 X AUC IV
c. AUC ora1 / AUC IV
d. None of the above
Q. The comparison of bioavailability between two dosage forms.
a. Bioequivalence
b. Bioavailability
c. Biopharmaceutics
d. Biological
Q. The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs.
a. Biological
b. Bioavailability
c. Biopharmaceutics
d. Bioequivalency
Q. Bioavailability of an intravenous drug is always 100% by definition because:
a. Bioavailability measures the amount of substance that reaches the bloodstream.
b. Absolute bioavailability is 50%, for any drug taken intravenously
c. Absolute bioavailability is a much more important measure than relative bioavailability
d. Intravenous administration gets the drug into your bloodstream the fastest.