Top 80+ Solved Drug Distribution MCQ Questions Answer
Q. Which process involve alteration of drug distribution
a. Competitive binding
b. Reduced plasma protein level
c. Both
d. None
Q. If drug have very small volume of distribution it is likely that the drug
a. Has short biological half life
b. Does not accumulate in various tissue and organ
c. Not bioavailable
d. will not be effective
Q. If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the givenstatement is true?
a. Apparent volume of distribution of drug X decrease
b. Free concentration of drug X in blood will be increase
c. Apparent volume of distribution of drug Y decrease
d. Toxicity of drug Y increase
Q. The distribution of drugs into the central nervous system (brain) usually depends on:
a. Aqueous diffusion
b. Lipid diffusion
c. Active transport
d. Facilitated tr
Q. Which of the following is most likely to be associated with a high apparent volume of distribution
a. High hepatic extraction ratio
b. Penetration across the blood:brain and blood:testes barriers
c. Extensive binding to plasma protein
d. Extensive binding to tissue constituents
Q. The Initial distribution of drug into the tissue is determined chiefly by
a. Rate of blood flow to tissue
b. Plasma protein binding of drug
c. Affinity for tissue
d. Gastric emptying time
Q. Transfer of drug from plasma to tissue depends on
a. Weight of tissue
b. Blood perfusion rate of tissue
c. Size of tissue
d. All of the above
Q. A hydrophilic medicinal agent has
a. Low ability to penetrate through the cell membrane lipids
b. Easy permeation through the blood-brain barrier
c. Penetrate through membranes by means of endocytosis
d. High reabsorption in renal tubules
Q. Biological barriers include all except:
a. Renal tubules
b. Cell membranes
c. Capillary walls
d. Placenta
Q. If a CNS drug is extensively ionized at pH of blood it will
a. Penetrate the blood brain barrier slowly
b. Penetrate the blood brain barrier rapidly
c. Not penetrate blood brain barrier
d. Be eliminated slowly
Q. The rate of drug transport across a cell membrane by lipid diffusion depends on all of the followingexcept
a. Drug size (diffusion constant)
b. Surface area of absorption
c. Lipid partition coefficient
d. Density of tr
Q. The formula to calculate half life (t1/2) is
a. 0.693 *Vd / C1
b. 0.693 *Cl / Vd
c. 0.693 / Cl * Vd
d. 0.693 / Cl
Q. The procedure of transporting a drug from the bloodstream to tissues is called as
a. Absorption
b. Dissolution
c. Distribution
d. Elimination
Q. …………..it represents the degree to which a drug is distributed in body tissue rather than
a. Volume of distribution (YD)
b. Effect of distribution
c. Area of distribution
d. None of the above