Top 80+ Solved Drug Distribution MCQ Questions Answer
Q. Plasma Protein binding …………..the volume of distribution of drugs.
a. increases
b. decreases
c. no change
d. none of the above
Q. Following intravenous administration, drugs are distributed fastest to:
a. the skin, kidney, and brain
b. the liver, kidney, and brain
c. the liver, adipose, and brain
d. the liver, kidney, and adipose
Q. …………is the tight junction between sertoli cells.
a. BBB
b. placental barrier
c. blood-testis barrier
d. endothelial barrier
Q. Distribution is……………..
a. irreversible process
b. dynamic equilibrium process
c. Both (a) & (b)
d. none of the above
Q. A drug reverses plasma-protein binding is often referred as……..
a. displacer
b. solvate
c. carrier substance
d. protein hydrolysate
Q. Primary binding site for albumin is ………………binding site.
a. Warfarin
b. Diazepam
c. Digitoxin
d. Tamoxifen
Q. Which of the following strategies are widely used to improve or promote transport of drug to brain?
a. Glycosylation
b. Use of Mannitol
c. Prodrug approach
d. All of the above
Q. Protein binding ……………the distribution of drugs.
a. Decreases
b. Increases
c. No Change
d. none of the above
Q. Which one of the following physicochemical property is more important for passive diffusion of drugs from the GIT?
a. Partition coefficient
b. Lipid solubility
c. pH of GIT fluids
d. dissolution constant
Q. Drug permeation through BBB can be improved by………..
a. Glycosylation
b. Mannitol
c. Dihydropyridine redox system
d. all of the above
Q. Which of the following drug diffuses readily into the brain?
a. Penicillin
b. Thiopental
c. Dopamine
d. all of the above