Top 80+ Solved Excretion of Drugs MCQ Questions Answer
Q. Drug elimination involves....... (ADME are steps of pharmacokinetics)
a. ADME
b. DME
c. ME
d. E only
Q. Filtration fraction is
a. Fraction of plasma passing through the kidney which is filtered at glomerulus
b. Ratio of iulin clearance to PAH clearance
c. Ration of CFR to RPF
d. None of them
Q. Creatinine clearance is used as measurement for
a. Glomerular filtration rate
b. Renal excretion rate
c. Passive renal excretion
d. Drug metabolism rate
Q. What is the half life of a drug with a volume of distribution of 100U70kg and a clearance of 7t/hr/70kg
a. 15 hours
b. 10 hours
c. 13.5 hours
d. 5 hours
Q. A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate ofblood flow to the liver would be
a. 60 milliliters/min
b. 120 milliliters/min
c. 650 milliliters/min
d. 1500 milliliters/min
Q. Which process involves alteration in drug excretion?
a. Increased fluid flow
b. Changes in urinary pH
c. Both
d. None
Q. Which of the following is not a step of renal excretion?
a. Glomerular filtration
b. Tubular filtration
c. Tubular reabsorption
d. Secretion
Q. Renal clearance is expressed as
a. Rate of urinary excretion / Plasma drug concentration
b. Elimination Rate / Plasma drug concentration
c. Rate of urinary excretion / Elimination Rate
d. Elimination Rate
Q. Glomerular filtration rate would be increased by
a. constriction of the afferent arteriole
b. decrease in afferent arteriolar pressure
c. compression of the renal capsule
d. decrease in the concentration of plasma protein
Q. The volume of plasma needed each minute to supply a substance at the rate at which it is excreted inthe urine is known as the
a. diffusion constant of the substance
b. clearance of the substance
c. extraction ratio of the substance
d. filtration rate of the substance
Q. Hepatic extraction ratio of 0.60 indicates that
a. 40% drug is left after extraction by the liver
b. 60% drug is left after extraction by the liver
c. Only 0.6% drug is removed by the liver
d. None of the above
Q. The term "biotransformation" includes the following.
a. Accumulation of substances in a fat tissue
b. Process of physicochemical and biochemical alteration of a drug in the body
c. Binding of substances with plasma proteins
d. Accumulation of substances in a tissue
Q. For the calculation of the volume of distribution (Vd) one take into account:
a. Concentration of a substance in urine
b. Concentration of substance in plasma
c. A daily dose of drug
d. Therapeutic width of drug action