Top 80+ Solved Excretion of Drugs MCQ Questions Answer
Q. Biotransformation of a medicinal substance results in:
a. Slower urinary excretion
b. Faster urinary excretion
c. Higher binding to membranes
d. Easier distribution in organism
Q. Biotransformation of the drugs is to render them:
a. Less lipid soluble
b. More lipid soluble
c. More pharmacologically active
d. Less ionized
Q. Select the right statement.
a. Microsomal oxidation results in a decrease of compound toxicity
b. Microsomal oxidation results in an increase of ionization and water solubility of a drug
c. Microsomal oxidation always results in inactivation of a compound
d. Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated
Q. Choose the drug type for which microsomal oxidation is the most prominent.
a. Water soluble
b. Lipid soluble
c. High molecular weight
d. Low molecular weight
Q. Metabolic transformation (phase 1) is:
a. Glucuronide formation
b. Binding to plasma proteins
c. Acetylation and methylation of substances
d. Tr
Q. Which of the following processes proceeds in the second phase of biotransformation?
a. Acetylation
b. Reduction
c. Oxidation
d. Hydrolysis
Q. Conjugation is:
a. Process of drug reduction by special enzymes
b. Process of drug oxidation by special oxidases
c. Coupling of a drug with an endogenous substrate
d. Solubilization in lipids
Q. Tick the drug type for which microsomal oxidation is the most prominent:
a. Lipid soluble
b. Water soluble
c. Low molecular weight
d. High molecular weight
Q. Stimulation of liver microsomal enzymes can:
a. Require the dose increase of some drugs
b. Require the dose decrease of some drugs
c. Prolong the duration of the action of a drug
d. Intensify the unwanted reaction of a drug
Q. Conjugation of a drug includes the following except:
a. Glucuronidation
b. Sulfate formation
c. Hydrolysis
d. Methylation
Q. The renal clearance of inulin is used as a measurement of
a. effective renal blood flow
b. rate of renal drug excretion
c. active renal secretion
d. glomerular filtration rate
Q. p-aminohippurate is used to measure
a. effective hepatic blood flow
b. effective renal blood flow
c. CFR
d. None of the above
Q. Total body clearance is
a. the drug elimination rate divided by the plasma drug concentration
b. the drug elimination rate divided by the Vd
c. the amount of drug in body divided by the plasma drug concentration
d. None of the above
Q. Renal excretion of drug depend on
a. urine flow
b. pH of urine
c. Physicochemical properties of drug
d. All of above
Q. For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximumclearance is approximately
a. 1-2 milliliters/min
b. 12 milliliters/min
c. 120 milliliters/min
d. 1200 milliliters/min