Top 50+ Solved Nonlinear Pharmacokinetics MCQ Questions Answer
Q. Non-linear pharmacokinetics is also known as………
a. dose dependent
b. enzyme capacity limited
c. saturation pharmacokinetics
d. All of the above
Q. The characteristic of non-linear pharmacokinetics include…………..
a. Area under the curve is proportional to the dose
b. Elimination half-life remains constant
c. Area under the curve is not proportional to the dose
d. Amount of drug excreted through remains constant
Q. Which of following drug shows non-linearity in hepatic excretion?
a. Carbamazepine
b. Propranolol
c. Penicillin
d. Thiopental
Q. Pharmacokinetics parameters change as per………… of dose administered?
a. Size
b. Route
c. Both of free above
d. None of the above
Q. Linear Pharmacokinetics is………………
a. Dose dependent
b. Dose independent
c. Both of the above
d. None of the above
Q. Non-linear Pharmacokinetics also called as…………
a. Mixed order
b. Saturated kinetics
c. Capacity Limited
d. All of the above
Q. In…………..Pharmacokinetic parameters for a drug can change with change in dose.
a. Linear Pharmacokinetics
b. Non-linear Pharmacokinetics
c. Both of the above
d. None of the above
Q. The………………….. is common cause of both dose and time dependent kinetics
a. Capacity limited Process
b. Dose volume
c. Enzyme induction
d. None of the above
Q. Active processes which are Saturable in renal excretion of drug includes…….
a. Active tubular secretion
b. Active tubular reabsorption
c. Both of the above
d. None of the above
Q. Linear Pharmacokinetics also referred as………….
a. First-order kinetics
b. Second order kinetics
c. Pseudo order kinetics
d. None of the above in
Q. If the steady-state plasma concentration is directly proportional to the dose, then ……….in thekinetics exists.
a. Linearity
b. Non-linearity
c. Both of the above
d. None of the above
Q. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantifiedby an accumulation factor R.
a. Accumulation Index
b. Apparent volume of drug distribution
c. Accumulation factor
d. None of the above
Q. Which of the following is correct statement about Nonlinear pharmacokinetics?
a. The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered
b. The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line.
c. the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
d. None of the above
Q. Which of the following Factors causing Non-linearity?
a. Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination.
b. Nonlinearity may arise due to Capacity-limited metabolism.
c. Nonlinearity may arise due to alteration in protein binding characteristics
d. All of the above