Top 50+ Solved Nonlinear Pharmacokinetics MCQ Questions Answer
Q. In Michaelis-Menton Equation, When the value of Km = C
a. rate of process is half (1 /2) the maximum rate.
b. the elimination of most drugs follows first order kinetic
c. the elimination of most drugs follows zero order kinetic
d. the elimination of most drugs follows second order kinetic
Q. Name the different methods used to estimate Km and Vmax graphically.
a. Direct Linear plot
b. Lineweaver —Burke plot or Klotz Plot
c. Graphical Method
d. All of the above
Q. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particulardrug.
a. True
b. False
c. none
d. all
Q. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
a. When absorption is solubility or dissolution rate-limited
b. When absorption involves carrier-mediated transport systems
c. When a presystemic gut wall or hepatic metabolism attains saturation
d. Saturation of binding sites on plasma proteins
Q. Which one of these is correct Michaelis-Menten equation?
a. –dC/dt = Vmax C/Km+C
b. dC/dt = Vmax C/Km+C
c. –dC/dt = Vmax C/Km
d. –dC/dt = Km+C / Vmax C