Top 80+ Solved Excretion of Drugs MCQ Questions Answer
Q. Which drugs cannot be filtered through glomerulus?
a. Drugs bound to plasma proteins
b. Unbound
c. Free drug
d. Below molecular weight of 300 Dalton
Q. Which one is the correct equation to calculate fraction of unbound drug in plasma?
a. Concentration of unbound drug in plasma / total plasma concentration of drug
b. Total plasma concentration of drug / Concentration of unbound drug in plasma
c. 1/Concentration of unbound drug in plasma
d. 1/total plasma concentration of drug
Q. What is total systemic clearance?
a. Sum of clearance from kidney
b. Sum of clearance from kidney and liver
c. Sum of clearance form non-renal clearances
d. Sum of renal and non-renal clearances
Q. What is the equation for clearance?
a. Elimination rate / plasma drug concentration
b. Plasma drug concentration/elimination rate
c. 1 / Plasma drug concentration
d. 1 / Elimination rate
Q. What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml?
a. 104g/min
b. 140g/min
c. 130g/min
d. 100g/min
Q. What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drugconcentration is 4.2 ng/ml?
a. 148.80ml2/ng min
b. 150ml2/ng min
c. 152ml2/ng min
d. 140ml2/ng min
Q. How renal clearance ratio is expressed?
a. Renal clearance of creatinine / renal clearance of the drug
b. 1/renal clearance of the drug
c. Renal clearance of drug/ renal clearance of creatinine
d. 1/renal clearance of creatinine
Q. What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearanceof creatinine is 95ml/min?
a. 0.421
b. 2.38
c. 0.010
d. 0.025
Q. How do you calculate the rate of excretion by kidneys?
a. Rate of filtration – the rate of secretion – Rate of absorption
b. Rate of filtration + rate of secretion – Rate of absorption
c. Rate of filtration + rate of secretion + Rate of absorption
d. Rate of filtration – the rate of secretion + Rate of absorption
Q. What will be the rate of filtration if the rate of secretion is 0.9 ml/ sec, rate of reabsorption is 0.2 ml/sec and the rate of excretion is 2ml/sec for a particular drug?
a. 3ml/sec
b. 0.3ml/sec
c. 1ml/sec
d. 1.3ml/sec
Q. Which one of the following is the principal organ for drug excretion?
a. Lungs
b. Liver
c. Kidneys
d. Sweat glands
Q. Compounds excreted in bile is classified into 3 categories. Which one of the following does not comeunder the categories?
a. Drugs with bile/plasma concentration ratio approximately 1
b. Drugs with bile/plasma concentration ratio between 10-1000
c. Drugs with bile/plasma concentration ratio of less than 1
d. Drugs with bile/plasma concentration ratio above 1000
Q. What is the molecular weight cut off for biliary excretion?
a. Less than 300 Dalton
b. More than 300 Dalton
c. Less than 200 Dalton
d. More than 200 Dalton
Q. What is the equation for biliary clearance?
a. No such equation is there
b. Biliary excretion rate/ plasma drug concentration
c. Plasma drug concentration / biliary excretion rate
d. Plasma drug concentration / Bile flow * biliary drug concentration
Q. For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?
a. 1.50 ml/mm
b. 1.75 ml/mm
c. 2.75 ml/mm
d. 3 ml/mm