Top 80+ Solved Drug Distribution MCQ Questions Answer
Q. Drug distribution in an organ depends on…………
a. Organ size
b. Perfusion rate
c. Partition Coefficient
d. all of the above
Q. Protein binding of acidic drugs decreased in………..
a. Trauma
b. Surgery
c. Hepatic Cirrhosis
d. Burns
Q. Which one of the following sentences will be the actual definition of distribution?
a. Transfer of drug from the administration dosage to surrounding fluid
b. Transfer of drug from the surrounding the fluid to the blood
c. Transfer of the drug from the oral cavity to the intestine
d. Reversible tr
Q. What should be the molecular weight of the drug molecules so that they can easily pass through the membrane?
a. 600-800 Dalton
b. 500-600 Dalton
c. 300-500 Dalton
d. 200-400 Dalton
Q. Which type of drug cannot enter the cell membrane in the below picture?
a. Ionized drug
b. Unionized drug
c. Hydrolyzed drug
d. Unhydrated drug
Q. Which drugs cannot pass the Capillary endothelial Barrier?
a. Molecular size less than 600 Dalton
b. Drugs bound to blood components
c. Drugs bound to a chemical moiety
d. All drugs can pass
Q. Which of the following drug cannot pass through the plasma membrane barrier?
a. Drug size less than 50 Dalton
b. Lipophilic drugs 50-600 Dalton
c. Polar or ionized drugs of size greater than 50 Dalton
d. Drug size more than 600 Dalton
Q. Which cell make up the blood-brain barrier?
a. Squamous epithelium cells
b. Fat cells
c. Red blood cell
d. Endothelial cells
Q. What is the name of the specialized cells that support the blood-brain barrier tissue?
a. Astrocytes
b. Dendrites
c. Fat cells
d. Endothelial cells
Q. Why dopamine cannot be administered for the disease Parkinsonism?
a. Don’t have a medicine
b. It is not the medicine
c. Cannot cross the blood-brain barrier
d. Forms aggregate and thus cannot cross the BBB
Q. Which one of these is not an approach to make the drug cross the blood-brain barrier?
a. Using permeation enhancers
b. Osmotic disruption of the blood-brain barrier
c. Use of highly lipophilic drug only
d. Use of drug carriers to cross the BBB
Q. Which drugs can easily pass the Placental barrier?
a. Drugs having a molecular weight less than 1000 Dalton
b. Moderate to high lipid solubility
c. Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics
d. Analgesics, antibiotics, etc
Q. What is the function of the blood-testis barrier?
a. Restricts the passage of drug to the testis
b. Restricts the passage of drug to sperms
c. Restricts the passage of drugs to spermatocytes
d. Restricts the passage of drugs to spermatocytes and spermatids
Q. What is the perfusion rate?
a. The total volume of blood
b. The volume of blood that flows through the heart per unit time
c. The volume of blood that flows per unit time per unit volume of tissue
d. The volume of tissue that flows per unit time per unit area of a blood vessel
Q. Who has more intracellular and extracellular water more in their body?
a. Aged
b. Adults Of age more than 20
c. Infants
d. Children at puberty