Top 80+ Solved Drug Distribution MCQ Questions Answer
Q. It is defined as the distribution of a drug between plasma and the rest of the body after oral orparenteral dosing.
a. Volume of distribution (VD)
b. Apparent volume of drug distribution
c. Phagocytosis
d. None of the above
Q. The drugs having molecular size …………..easily cross capillary membrane.
a. <500-600d
b. < 100-200 d
c. <300-600d
d. <90M600d
Q. The concentration of drug in blood or plasma will be comparatively in the GI tract.
a. High
b. Low
c. Very High
d. Very Low
Q. Fat is act as reservoir for……………………… Drugs
a. Highly water soluble
b. Lower lipid soluble
c. Highly lipid soluble
d. Lower lipid soluble
Q. Displacement is significant when, the displaced drug is more than protein bound.
a. 50%
b. 95%
c. 10%
d. 1%
Q. ……………is located at the sertoli-sertoli cell junction.
a. Blood testis barrier
b. Blood CSF barrier
c. Blood cellular barrier
d. All of the above
Q. The Binding Order of drug to tissue is…………………
a. Kidney > Liver > Lungs > Muscle
b. Muscle > Kidney > Lungs > Liver
c. Liver > Kidney > Lungs > Muscle
d. Liver > Lungs > Kidney > Muscle
Q. …………………in lipophilicity increases the extend of binding.
a. Increase
b. Decrease
c. Constant
d. None of the above
Q. Protein binding of drugs helps to maintain ……………for absorption of drugs.
a. non sink condition
b. sink condition
c. pKa
d. none of the above
Q. The loading dose of a drug is based upon the
a. time taken for complete elimination
b. percentage of drug excreted unchanged in urine
c. percentage of drug bound to plasma protein
d. apparent volume of distribution and the desired drug concentration in plasma
Q. The volume of distribution of drugs is:
a. An expression of total body volume
b. A measure of total fluid volume
c. A relationship between the total amount of drug in the body and the concentration of the drug in the blood
d. Proportional to bioavailability of the drug
Q. The volume of distribution (Vd) relates:
a. Single to a daily dose of an administered drug
b. An administered dose to a body weight
c. An unchanged drug reaching the systemic circulation
d. The amount of a drug in the body to the concentration of a drug in plasma
Q. Movement of drug across the membrane is called as
a. Symport
b. Antiport
c. Drug transport
d. Absorption
Q. Which of the following is known as Tamoxifen binding site?
a. Site I
b. Site II
c. Site III
d. Site IV
Q. Which of the following drug selectively bound to extravascular tissues?
a. Warfarin
b. Diazepam
c. Digitoxin
d. Chloroquin