Top 150+ Solved Pharmaceutical Chemistry - Medicinal Chemistry 4 MCQ Questions Answer
Q. The most important complication of streptokinase therapy is:
a. Hypotension
b. Bleeding
c. Fever
d. Anaphylaxis
Q. Aspirin prolongs bleeding time by inhibiting the synthesis of:
a. Clotting factors in liver
b. Prostacyclin in vascular endothelium
c. Cyclic AMP in platelets
d. Thromboxane A2 in platelets
Q. The following is true of clopidogrel except:
a. It is a GPIIb/IIIa receptor antagonist
b. It inhibits fibrinogen induced platelet aggregation
c. It is indicated for prevention of stroke in patients with transient ischaemic attacks
d. It is a prodrug
Q. Choose the most potent and most efficacious LDL cholesterol lowering HMG-CoA reductaseinhibitor:
a. Lovastatin
b. Simvastatin
c. Pravastatin
d. Atorvastatin
Q. Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level butnormal triglyceride level:
a. A HMG-CoA reductase inhibitor
b. A fibric acid derivative
c. Gugulipid
d. Nicotinic acid
Q. Plasma expanders are used in the following conditions except: (Note: They will increase circulating blood volume and thus preload on heart, which will worsen heart failure.)
a. Congestive heart failure
b. Extensive burns
c. Mutilating injuries
d. Endotoxin shock
Q. Trapping of iodide by the following organ/organs is enhanced by thyrotropin:
a. Thyroid
b. Salivary gland
c. Placenta
d. All of the above
Q. Triiodothyronine differs from thyroxine in that:
a. It is more avidly bound to plasma proteins
b. It has a shorter plasma half life
c. It is less potent
d. It has a longer latency of action
Q. The most reliable guide to adjustment of thyroxine dose in a patient of hypothyroidism is:
a. Pulse rate
b. Body weight
c. Serum thyroxine level
d. Serum TSH level
Q. Actions of thyroxine include the following except:
a. Induction of negative nitrogen balance
b. Reduction in plasma cholesterol level
c. Fall in plasma free fatty acid level
d. Rise in blood sugar level
Q. acts by inhibiting:
a. Iodide trapping
b. Oxidation of iodide
c. Proteolysis of thyroglobulin
d. Synthesis of thyroglobulin protein
Q. Antithyroid drugs exert the following action:
a. Inhibit thyroxine synthesis
b. Block the action of thyroxine on pituitary
c. Block the action of TSH on thyroid
d. Block the action of thyroxine on peripheral tissues
Q. The following thyroid inhibitor interferes with peripheral conversion of thyroxine totriiodothyronine:
a. Propyl thiouracil
b. Methimazole
c. Carbimazole
d. Radioactive iodine
Q. The uses of sodium/potassium iodide include the following except:
a. Preoperative preparation of Grave’s disease patient
b. Prophylaxis of endemic goiter
c. As antiseptic
d. As expectorant