Top 150+ Solved Pharmaceutical Chemistry - Medicinal Chemistry 4 MCQ Questions Answer
Q. The following is not true about :
a. It blocks myocardial Na+ channels primarily in the open state
b. It has no effect on myocardial K+ channels
c. It produces frequency dependent blockade of myocardial Na+ channels
d. It delays recovery of myocardial Na+ channels
Q. Beneficial effect/effects of diuretics in CHF patients include the following:
a. Symptomatic relief
b. Regression of pathological changes
c. Prolongation of life expectancy
d. Both ‘A’ and ‘C’
Q. Glyceryl trinitrate is used in CHF for:
a. Routine treatment of mild to moderate chronic heart failure
b. Rapid symptom relief in acute left ventricular failure
c. Arresting disease progression
d. Both 'A' and 'B'
Q. Vasodilators are used to treat:
a. Acute heart failure attending myocardial infarction
b. Chronic heart failure due to diastolic dysfunction
c. Chronic heart failure due to both systolic as well as diastolic dysfunction
d. All of the above
Q. Given drug is administered by the following routes except:
a. Oral
b. Sublingual
c. Intramuscular
d. Intravenous
Q. Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina?
a. Propranolol
b. Atenolol
c. Verapamil
d. Dipyridamole
Q. The following antianginal drug is most likely to produce tachycardia as a side effect:
a. Amlodipine
b. Nifedipine
c. Diltiazem
d. Verapamil
Q. The cardiac response to verapamil and nifedipine in human subjects is:
a. Verapamil causes tachycardia while nifedipine causes bradycardia
b. Both cause bradycardia
c. Verapamil causes bradycardia while nifedipine causes tachycardia
d. Both cause tachycardia
Q. Propranolol should not be prescribed for a patient of angina pectoris who is already receiving:
a. Nifedipine
b. Felodipine
c. Verapamil
d. Isosorbide mononitrate
Q. The short acting dihydropyridine preparations can aggravate myocardial ischaemia by invoking:
a. Coronary vasospasm
b. Thrombus formation
c. Vagal activation
d. Reflex sympathetic discharge to the heart
Q. Which of the following drugs is a potassium channel opener?
a. Nicorandil
b. Hydralazine
c. Glibenclamide
d. Amiloride
Q. The characteristic feature(s) of dihydropyridine calcium channel blockers is/are:
a. They have minimal negative inotropic action on the heart
b. They have no effect on A-V conduction
c. They do not affect the activation-inactivation kinetics of the calcium channels
d. All of the above
Q. The dihydropyridines block the following type of calcium channels:
a. L-type voltage sensitive channels
b. T-type voltage sensitive channels
c. N-type voltage sensitive channels
d. Receptor operated calcium channels
Q. Select the drug which is a potassium channel opener as well as nitric oxide donor:
a. Diazoxide
b. Sodium nitroprusside
c. Minoxidil
d. Nicorandil