Top 150+ Solved Pharmaceutical Chemistry - Medicinal Chemistry 4 MCQ Questions Answer
Q. Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate:
a. Coronary
b. Cutaneous
c. Renal
d. Cranial
Q. Phase II in cardiac action potential is
a. Fast depolarization
b. Partial repolarization
c. Plateau
d. Repolarization
Q. In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at
a. C- 15
b. C- 16
c. C-17
d. C -18
Q. 2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of
a. Flecainide
b. Atenolol
c. Verapamil
d. Lignocaine
Q. Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:
a. Glyceryl trinitrate
b. Isosorbide dinitrate
c. Isosorbide mononitrate
d. Erythrityl tetranitrate
Q. The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:
a. Increase in total coronary blood flow
b. Redistribution of coronary blood flow
c. Reduction of cardiac preload
d. Reduction of cardiac afterload
Q. Organic nitrates relax vascular smooth muscle by:
a. Increasing intracellular cyclic GMP
b. Increasing intracellular cyclic AMP
c. Decreasing intracellular cyclic AMP
d. Both ‘A’ and ‘C’ are correct
Q. Nitrate tolerance is least likely to develop with the use of:
a. Sustained release oral glyceryl trinitrate
b. Sublingual glyceryl trinitrate
c. Transdermal glyceryl trinitrate
d. Oral pentaerythritol tetranitrate
Q. Glyceryl trinitrate is administered by the following routes except:
a. Oral
b. Sublingual
c. Intramuscular
d. Intravenous
Q. Myocardial Na+ channel blockade by lignocaine has the following characteristic:
a. It blocks inactivated Na+ channels more than activated channels
b. It blocks activated Na+ channels more than inactivated channels
c. It delays rate of recovery of Na+ channels
d. It produces more prominent blockade of atrial than ventricular Na+ channels
Q. Hypothyroidism is a possible consequence of prolonged therapy with:
a. Amiodarone
b. Mexiletine
c. Sotalol
d. Procainamide
Q. The following is true of procainamide except:
a. It generates an active metabolite in the body
b. Its plasma half-life is longer than that of quinidine
c. On long-term use, it can cause systemic lupus erythematosus like illness
d. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine
Q. The most significant feature of the antiarrhythmic action of is:
a. Suppression of phase-4 depolarization in ventricular ectopic foci
b. Prolongation of action potential duration
c. Prolongation of effective refractory period
d. Depression of membrane responsiveness
Q. Quinidine is now used primarily for:
a. Conversion of atrial fibrillation to sinus rhythm
b. Control of ventricular rate in atrial flutter
c. Termination of ventricular tachycardia
d. Prevention of recurrences of atrial fibrillation/ ventricular tachycardia
Q. The following antiarrhythmic drug has the most prominent anticholinergic action:
a. Disopyramide
b. Quinidine
c. Procainamide
d. Lignocaine