Top 80+ Solved General Physiology MCQ Questions Answer
Q. For the Erlanger and Gasser classification, which is TRUE?
a. Sunday morning syndrome mainly affects C fibres
b. local anaesthetics primarily affect A fibres
c. preganglionic autonomic fibres are type B
d. C fibres have the largest diameter
e. B fibres are the least susceptible to hypoxia
Q. For the glial cells, which is TRUE?
a. one schwann cell can myelinate up to 40 neurons
b. oligodenotocytes are the scavenger cells of the CNS
c. microglia are the scavenger cells of the PNS
d. there are up to three glial cells per neuron in the nervous system
e. protoplasmic astrocytesase found in grey matter
Q. For cardiac muscle, which is FALSE?
a. HERG really is the acronym for human ether-a-go-go related gene
b. intercolated discs are calcified structures within cardiac muscle cells
c. resting membrane potential is -90mV
d. cardiac muscle requires continuous supply of O2 to function
e. cardiac muscle action potential time decreases with increasing heart rate
Q. Regarding body water, which is FALSE?
a. 1/3 total body weight is extra and 2/3 intra cellular
b. 60% of body weight is water
c. plasma is 8% and total blood 10%, of body weight
d. of extracellular fluid, 25% is vascular, 75% extravascular
e. interstitial fluid is 15% of body weight
Q. Chemical composition, which is TRUE?
a. pH is the negative natural logarithm of [H+]
b. pH 5 to pH 6 involves tenfold increase in [H+]
c. pH remains 7.4 +/- 0.05 in ECF, stabilised by buffer
d. H2O and CO2 H2CO3 H+ and HCO3-, adding H+ shifts the equilibrium to the right, while adding ??? shifts it to the left
e. the Donnan effect does not contribute significantly to the balance of electrolyte between intra and extra vascular compartment
Q. Nerve fibres, which is FALSE?
a. 70% of energy requirement of nerves is used in maintaining polarity across the recytlemina by action of Na-K ATPase
b. metabolic rate of nerves doubles in max action
c. “C” type fibres are non-myelinated and include some of the sympathetic preganglionic fibres
d. “A” and “B” fibres are all myelinated
e. effects of local anaesthetic are maximal in “C” fibres
Q. Regarding skeletal muscle, which is FALSE?
a. metabolic rate of muscle may increase 100 times in maximal activity
b. muscle cells can be excited chemically, mechanically and electrically, to produce action potentials in the cell membrane
c. actin is a myosin-binding protein which is a molecular motor, converting ATP energy to monomers
d. mitochondria are packed in between myofibrils
e. T tubules occur over the junction of I and A bands
Q. More on muscles; which is TRUE?
a. skeletal muscle cells act as syncytram, though intercellular communications
b. some skeletal muscles are not subject to voluntary control
c. smooth muscle contains regularly discharging pacemaker
d. a variant of smooth muscle is found in the eye, which resembles skeletal muscle
e. cardiac muscle does not contain regular striation
Q. More on muscles; which is FALSE?
a. T tubules are extensions of extracellular space
b. “cystems’ of SR are in contact with T-tubules
c. myosin molecules combine to form thick filaments while actin, tropomyosin, and the troponins the t…..
d. an individual muscle cell is a myofibril, containing myofilaments
e. the sarcolemnia transmits action potentials
Q. In muscle construction, which is TRUE?
a. only contraction is energy requiring, not relaxing
b. sequestering of Ca2+ causes separation of actin-myosin bands and muscle relaxation
c. ATPase clefts are on the tips of the myosin beads
d. ryanodine receptors are voltage gated Ca2+ chains
e. Troponin T inhibits the interaction of actin and myosin
Q. Action potentials:
a. travel along neurons at a set velocity
b. are only seen in neurons
c. are generated initially by action of K+ voltage gated channels
d. result from variation in Na+ and K+ membrane permeability
e. are unidirectional impulses
Q. The golgi apparatus, which is TRUE?
a. is found only in secretory cells
b. vesicles containing newly synthesised proteins bind to trans side of the apparatus
c. constitutive pathway of cell secretion is responsible for further processing and storage of proteins
d. is responsible for glycorylation of proteins
e. none of the above
Q. With respect to protein synthesis:
a. each amino acid found in human protein has its own individual single transfer RNA
b. pre mRNA processing occurs in the cytoplasm prior to binding to ribosomes on the endoplasmic retic???
c. each gene has regulatory, promoter, coding and non coding regions which are all transcribed into pre mRNA
d. introns no recognised physiological function
e. the promoter site of a gene is the site where RNA polymerase binds
Q. Which is TRUE?
a. polymerase chain reaction may be used to repair damaged DNA
b. restriction fragment length polymorphism detects differences in DNA sequences between different individuals
c. protein encoding genes make up only 15% of the human genome
d. the only difference between DNA and RNA is the substitution of uracil for thymine
e. the haploid human genome is made up of 3 X 106 base pairs
Q. Action potentials in skeletal muscle:
a. travel along muscle fibres at varying rates
b. have larger retratory periods compared to nerves
c. causes uptake of Ca++ into sacroplasmic reticulum
d. results in sustained contraction of muscle fibres
e. the haploid human genome is made up of 3 X 106 base pairs