Top 80+ Solved General Physiology MCQ Questions Answer
Q. Regarding cellular components:
a. peroxisomes are larger than lysosomes
b. pH of lysosomes is higher than the rest of the cytoplasm
c. microfilaments are hollow
d. myosin 1 molecules are characteristically found in muscle cells
e. microfilaments are made up of actin
Q. Which decreases Na+ -K+ -ATPase pump activity?
a. thyroid hormones
b. dopamine
c. G-actin
d. intracellular sodium
e. insulin
Q. Given that a person weighs 60kg and their haematocrit is 40%, their totalblood volume is:
a. 6L
b. 5L
c. 4L
d. 3L
e. cannot be calculated with the given information
Q. ECF volume can be estimated using:
a. inulin
b. D2O
c. Evan’s blue
d. radioactive chromium
e. iron isotopes
Q. The number of molecules in a mole is:
a. 1 X 1026
b. 6 X 1026
c. 4 X 1026
d. 1 X 1023
e. 6 X 1023
Q. The molecular mass of a substance is expressed in:
a. moles
b. Daltons
c. equivalents
d. osmoles
e. grams
Q. Regarding mitochondria:
a. genome inheritance is strictly maternal
b. the citric acid cycle occurs at the outer membrane
c. the space between the two membranes is called the matrix
d. the mutation rate for mitochondrial DNA is less than for nuclear DNA
e. involutions of the outer membrane are called cristae
Q. Which volume of distribution is evaluated with which substance?
a. plasma – D2O
b. RBC volume – 51Cr
c. ECF – Evans Blue
d. Interstitial fluid – Inulin
e. ICF – mannitol
Q. Which is correct?
a. blood volume is 8% total body weight
b. 2/3 total body weight is ECF
c. 75% of ECF is blood plasma
d. water content of lean tissue is 25%
e. total body water increases with increasing age
Q. For mitochondria, which is TRUE?
a. NADH-DH, 5DH, bc, cox synthesise ATP
b. the matrix is between the inner and outer mitochondrial DNA
c. mitochondrial DNA is not transmitted paternally
d. 99% of mitochondrial proteins are encoded by mitochondrial DNA
e. ATP synthetase is powered by an electron gradient
Q. Which is TRUE?
a. the cytoskeleton is composed of hydroxyapatites
b. the mitotic spindle is composed of actin microtubules
c. myosin is the most abundant protein in cells
d. colchicine stabilises microtubules preventing organelle movement
e. actin-myosin interaction allows cells to move
Q. For the genome, which is TRUE?
a. the human genome encodes 3 X 109 genes
b. adenine binds to cytosine and guanine to thymine
c. uracil replaces thymine in RNA
d. 3% of DNA are introns
e. haploid DNA in germ cells is single stranded
Q. For transmembrane movement, which is TRUE?
a. exocytosis requires Ca2+ and energy
b. Na+ -K+ -ATPase is an example of facilitated diffusion
c. amiloride activates epithelial Na+ channels
d. clathrin is essential for vesicle exocytosis
e. water can only enter cells via water channels