Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. Under compartment modeling, Wegner-Nelson-Method involves
a. Determination of absorption rate constant (Ka) from %ARA Vs time curve
b. Determination of elimination rate constant (Ka) from % ARA Vs time curve
c. Determination of absorption rate constant (Ke) from %ARA •Vs Concentration curve
d. Determination of plasma half life
Q. The steady-state concentration of a drug can be double by:
a. Doubling the both rate of infusion and concentration of drug.
b. Doubling the rate of infusion only.
c. Doubling the loading dose but maintaining the infusion rate.
d. Tripling the rate of infusion.
Q. In compartment modeling the term "Open" indicates
a. Unidirectional input and output
b. All compartments are open
c. Body is open
d. None of the above
Q. Select the formula to calculate steady state concentration follows IV infusion
a. Css= Infusion Rate/ Clearance
b. Css= Clearance / Infusion Rate
c. Css= Infusion Rate X Clearance
d. Css = Infusion Rate - Clearance
Q. IV infusion model follows
a. Zero order absorption and first order elimination kinetic
b. No absorption and first order elimination kinetic
c. No absorption and Zero order elimination kinetic
d. First order absorption and first order elimination kinetic
Q. Select the formula to calculate elimination half life
a. t1/2 = 0.693 + Ke
b. t1/2 = 0.693 / Ke
c. t1/2 = 0.693 × Ke
d. t1/2 = 0.693 – Ke
Q. The constants that represent reversible transfer of drug between compartments are called as
a. microconstants
b. macroconstant
c. Infusion
d. Lag time
Q. In two compartment model, extravascular route of drug administration, there are ……phases
a. absorption phase,
b. Distribution phase
c. elimination phase,
d. All of the above
Q. Ka is estimated by
a. Method of Residuals
b. Loo Riegelman method
c. Both a and b
d. None of the above
Q. The central compartment consist of
a. Highly perfused tissues
b. Slowly equilibrate tissues
c. Both a and b
d. Reproductive org
Q. What does "pharmacokinetics" includes?
a. Mechanisms of drug action
b. Localization of drug action
c. Interaction of substances
d. Excretion of substances
Q. Pharmacokinetics is:
a. The study of absorption, distribution, metabolism and excretion of drugs
b. The study of biological and therapeutic effects of drugs
c. The study of methods of new drug development
d. The study of mechanisms of drug action
Q. What does "pharmacokinetics" includes?
a. Drug biotransformation in the organism
b. Influence of drugs on metabolism processes
c. Influence of drugs on genes
d. Complications of drug therapy
Q. Parenteral administration:
a. Is too slow for emergency use
b. Cannot be used with unconsciousness patients
c. Generally results in a less accurate dosage than oral administration
d. Usually produces a more rapid response than oral administration
Q. The volume of distribution (Vd) relates:
a. The amount of a drug in the body to the concentration of a drug in plasma
b. An uncharged drug reaching the systemic circulation
c. Single to a daily dose of an administrated drug
d. An administrated dose to a body weight