Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. The extent to which a drug is distributed is a tissue depends upon ___________ and _____________
a. The concentration of a drug, tissue/blood partition coefficient of drug
b. Tissue volume, tissue/blood partition coefficient of drug
c. Tissue surface area, tissue/blood partition coefficient of drug
d. Blood density upon the tissue, tissue/blood partition coefficient of drug
Q. Which one of the following has a high perfusion rate?
a. Fat
b. Muscle and skin
c. Lungs and kidney
d. Bone
Q. Which one of the following has very low perfusion rate?
a. Fat and bone
b. Muscle and skin
c. Lungs and kidney
d. Liver and Heart
Q. Disease state of a patient can influence drug distribution across the body.
a. True
b. False
c. none
d. all
Q. In meningitis and encephalitis polar antibiotics gain access to BBB which don’t happen to a healthyperson.
a. True
b. False
c. none
d. all
Q. What reasons make tissue-drug binding important for drug distribution?
a. Increases the volume of distribution of drugs and results in localization of drug at a specific site
b. Increases the volume of distribution of drugs
c. Results in localization of drugs at a tissue specific site
d. Increases in absorption from the tissue due to concentration increasing
Q. Following is the order in decreasing order of drug binding to the extravascular tissue. Which one isthe correct order?
a. Liver > kidney > muscle > lung
b. Liver > muscle > lung > kidney
c. Liver > muscle > kidney > lung
d. Liver > kidney > lung > muscle
Q. What is the relation between halogenated hydrocarbon and liver?
a. Halogenated hydrocarbon is a drug for liver problems
b. Halogenated hydrocarbon is nutrition for liver
c. Halogenated hydrocarbon causes hepatotoxicity
d. Halogenated hydrocarbon forms the bile juices in liver
Q. Which drugs accumulate in liver?
a. Acidic drugs like imipramine
b. Basic drugs like imipramine
c. Halogenated hydrocarbons
d. Chloroquinine
Q. Which metals get accumulated in kidney?
a. Mercury, cadmium, lead
b. Mercury, cadmium, iron
c. Mercury, lanthanum, lead
d. Mercury, cadmium, fluoride ions
Q. Which of the following drugs accumulate in skin?
a. Acidic drugs like imipramine
b. Basic drugs like imipramine
c. Halogenated hydrocarbons
d. Chloroquine
Q. Which of the following drugs are responsible for retinopathy?
a. Acidic drugs like imipramine
b. Basic drugs like imipramine
c. Halogenated hydrocarbons
d. Chloroquinine
Q. Which drugs deposit in hair shafts?
a. Arsenicals
b. Tetracycline
c. Halogenated hydrocarbons
d. Lipophilic drug
Q. Which drug causes brown yellow discoloration of infant’s teeth?
a. Arsenicals
b. Tetracycline
c. Halogenated hydrocarbons
d. Lipophilic drug