Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. Which drugs cannot pass the Capillary endothelial Barrier?
a. Molecular size less than 600 Dalton
b. Drugs bound to blood components
c. Drugs bound to a chemical moiety
d. All drugs can pass
Q. Which of the following drug cannot pass through the plasma membrane barrier?
a. Drug size less than 50 Dalton
b. Lipophilic drugs 50-600 Dalton
c. Polar or ionized drugs of size greater than 50 Dalton
d. Drug size more than 600 Dalton
Q. Which cell make up the blood-brain barrier?
a. Squamous epithelium cells
b. Fat cells
c. Red blood cell
d. Endothelial cells
Q. What is the name of the specialized cells that support the blood-brain barrier tissue?
a. Astrocytes
b. Dendrites
c. Fat cells
d. Endothelial cells
Q. Why dopamine cannot be administered for the disease Parkinsonism?
a. Don’t have a medicine
b. It is not the medicine
c. Cannot cross the blood-brain barrier
d. Forms aggregate and thus cannot cross the BBB
Q. Which one of these is not an approach to make the drug cross the blood-brain barrier?
a. Using permeation enhancers
b. Osmotic disruption of the blood-brain barrier
c. Use of highly lipophilic drug only
d. Use of drug carriers to cross the BBB
Q. Which drugs can easily pass the Placental barrier?
a. Drugs having a molecular weight less than 1000 Dalton
b. Moderate to high lipid solubility
c. Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics
d. Analgesics, antibiotics, etc
Q. What is the function of the blood-testis barrier?
a. Restricts the passage of drug to the testis
b. Restricts the passage of drug to sperms
c. Restricts the passage of drugs to spermatocytes
d. Restricts the passage of drugs to spermatocytes and spermatids
Q. What is the perfusion rate?
a. The total volume of blood
b. The volume of blood that flows through the heart per unit time
c. The volume of blood that flows per unit time per unit volume of tissue
d. The volume of tissue that flows per unit time per unit area of a blood vessel
Q. Who has more intracellular and extracellular water more in their body?
a. Aged
b. Adults Of age more than 20
c. Infants
d. Children at puberty
Q. Who has higher fat content?
a. Adults of age above 70
b. Adults of age more than 20
c. Infants and elders
d. Children at puberty
Q. Who has poorly developed BBB?
a. Infants
b. Adults Of age more than 20
c. Aged
d. Children at puberty
Q. During pregnancy, drug distribution is more. Which of the following sentences describe the given fact better?
a. The baby needs more drug
b. The mother needs more drug due to high metabolism
c. The surface area increases in the mother’s body due to the presence of uterus, placenta, and foetus. Thus more area for distribution of drugs
d. The growth of the uterus, placenta, and foetus increases the volume thus increasing distribution. And even the baby forms a separate compartment for a drug to get distributed
Q. What happens when an obese person is given with a lipophilic drug?
a. Drug aggregation will begin
b. He cannot absorb lipophilic drugs
c. High adipose tissue take up most of the lipophilic drug
d. A large amount of drug is needed as the person’s weight is more
Q. What is the consequence of diet high in fats?
a. The patient can’t be given with acidic drugs
b. The patient can’t be given with basic drugs
c. The basic drugs will aggregate and become poisonous for him
d. The high fatty acid level affect the binding of acidic drugs