Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantifiedby an accumulation factor R.
a. Accumulation Index
b. Apparent volume of drug distribution
c. Accumulation factor
d. None of the above
Q. Which of the following is correct statement about Nonlinear pharmacokinetics?
a. The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered
b. The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line.
c. the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
d. None of the above
Q. Which of the following Factors causing Non-linearity?
a. Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination.
b. Nonlinearity may arise due to Capacity-limited metabolism.
c. Nonlinearity may arise due to alteration in protein binding characteristics
d. All of the above
Q. In Michaelis-Menton Equation, When the value of Km = C
a. rate of process is half (1 /2) the maximum rate.
b. the elimination of most drugs follows first order kinetic
c. the elimination of most drugs follows zero order kinetic
d. the elimination of most drugs follows second order kinetic
Q. Name the different methods used to estimate Km and Vmax graphically.
a. Direct Linear plot
b. Lineweaver —Burke plot or Klotz Plot
c. Graphical Method
d. All of the above
Q. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particulardrug.
a. True
b. False
c. none
d. all
Q. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
a. When absorption is solubility or dissolution rate-limited
b. When absorption involves carrier-mediated transport systems
c. When a presystemic gut wall or hepatic metabolism attains saturation
d. Saturation of binding sites on plasma proteins
Q. Which one of these is correct Michaelis-Menten equation?
a. –dC/dt = Vmax C/Km+C
b. dC/dt = Vmax C/Km+C
c. –dC/dt = Vmax C/Km
d. –dC/dt = Km+C / Vmax C
Q. Which process involve alteration of drug distribution
a. Competitive binding
b. Reduced plasma protein level
c. Both
d. None
Q. If drug have very small volume of distribution it is likely that the drug
a. Has short biological half life
b. Does not accumulate in various tissue and organ
c. Not bioavailable
d. will not be effective
Q. If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the givenstatement is true?
a. Apparent volume of distribution of drug X decrease
b. Free concentration of drug X in blood will be increase
c. Apparent volume of distribution of drug Y decrease
d. Toxicity of drug Y increase
Q. The distribution of drugs into the central nervous system (brain) usually depends on:
a. Aqueous diffusion
b. Lipid diffusion
c. Active transport
d. Facilitated tr
Q. Which of the following is most likely to be associated with a high apparent volume of distribution
a. High hepatic extraction ratio
b. Penetration across the blood:brain and blood:testes barriers
c. Extensive binding to plasma protein
d. Extensive binding to tissue constituents
Q. The Initial distribution of drug into the tissue is determined chiefly by
a. Rate of blood flow to tissue
b. Plasma protein binding of drug
c. Affinity for tissue
d. Gastric emptying time
Q. Transfer of drug from plasma to tissue depends on
a. Weight of tissue
b. Blood perfusion rate of tissue
c. Size of tissue
d. All of the above