Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. Under the concept biopharmaceutics, hydrophobic drugs are
a. Permeation rate limited
b. Dissolution rate limited
c. Both
d. Initially permeation then dissolution rate limited
Q. Which of the following methods are used to determine Area Under curve?
a. Cut and weigh method
b. Trapezoidal method
c. Integration method
d. All of the above
Q. Apparatus 5 of dissolution apparatus is known as
a. Paddle over disk
b. Flow-through- cell
c. Reciprocating disk
d. Basket
Q. Bioavailability differences among oral formulations of a drug are most likely to occur if the drug
a. Is freely water soluble
b. Is completely absorbed
c. Is incompletely absorbed
d. Undergoes little first-pass metabolism
Q. Bioavailability is expressed by formula
a. AUC IV / AUC oral
b. AUC ora1 X AUC IV
c. AUC ora1 / AUC IV
d. None of the above
Q. The comparison of bioavailability between two dosage forms.
a. Bioequivalence
b. Bioavailability
c. Biopharmaceutics
d. Biological
Q. The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs.
a. Biological
b. Bioavailability
c. Biopharmaceutics
d. Bioequivalency
Q. Bioavailability of an intravenous drug is always 100% by definition because:
a. Bioavailability measures the amount of substance that reaches the bloodstream.
b. Absolute bioavailability is 50%, for any drug taken intravenously
c. Absolute bioavailability is a much more important measure than relative bioavailability
d. Intravenous administration gets the drug into your bloodstream the fastest.
Q. Comparison of the rate and extent of the absorption of drug from the formulation under study to thedata of a reference standard that is given intravenously is known as:
a. Biopharmaceutics
b. Relative bioavailability
c. Absolute bioavailability
d. Bioavailability
Q. If the Relative Bioavailability is 1, it indicates:
a. Bioavailability of dosage form of one drug is same as that of the other dosage form
b. Complete binding of the drugs to the proteins as compared to the standard drug
c. Complete bioavailability of the drug
d. Complete distribution of the drug
Q. What would be the order of greater or lesser bioavailability of the dosage forms?
a. Intravenous > rectal > oral > topical
b. Intravenous > oral > rectal > topical
c. Intravenous > topical > rectal > oral
d. Oral > intravenous > rectal > topical
Q. The term bioavailability refers to the………….
a. relationship between the physical and chemical properties of a drug and the systemic absorption of the drug
b. measurement of the rate and amount of therapeutically active drug that reaches the systemic circulation
c. movement of drug into the body tissues over time
d. dissolution of a drug in the gastrointestinal tract
Q. The reasons determining bioavailability are…..
a. Rheological parameters of blood
b. Amount of a substance obtained orally and quantity of intakes
c. Extent of absorption and hepatic first-pass effect
d. Glomerular filtration rate