Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?
a. 1.50 ml/mm
b. 1.75 ml/mm
c. 2.75 ml/mm
d. 3 ml/mm
Q. Which compounds are excreted through the lungs?
a. Lipophilic
b. Gaseous
c. Liquid and hydrophilic
d. Solid less than 100 Dalton
Q. What is the mechanism of drug excretion for skin excretion?
a. Active secretion
b. Glomerular secretion
c. Passive diffusion
d. Passive reabsorption
Q. What is the mechanism of drug excretion for biliary excretion?
a. Active secretion
b. Glomerular secretion
c. Passive diffusion
d. Passive reabsorption
Q. Which of the following is not a factor influencing pulmonary excretion?
a. Pulmonary blood flow
b. The solubility of volatile substance
c. Rate of respiration
d. Heart rate
Q. How is renal clearance expressed mathematically?
a. Rate of urinary excretion/plasma drug concentration
b. Plasma drug concentration/rate of urinary excretion
c. 1/ Plasma drug concentration
d. 1/rate of urinary excretion
Q. What is the driving force for glomerular filtration?
a. Concentration gradient
b. Hydrostatic pressure of plasma
c. High amount of aqueous pores
d. Hydrostatic pressure of blood flow
Q. Which of the following compounds are used as agents to determine Glomerular Filtration Rate?
a. Calcium ion
b. Albumin
c. Creatinine
d. Calcium carbonate
Q. According to Biopharmaceutics Classification System (BCS), Class II drugs have
a. High solubility/High permeability
b. Low solubility /High permeability
c. High solubility /Low permeability
d. Low solubility /Low permeability
Q. ………………is the ratio of the mean residence time to the absorption time
a. Absorption number
b. Dissolution number
c. Dose number
d. Intrinsic dissolution
Q. In vitro dissolution rate studies on drug product are useful in bioavailability evaluation if they are correlated with
a. Disintegration rate
b. In vivo studies in at least 3 species of animals
c. Chemical stability of drugs
d. In vivo studies in human
Q. The gold coating on a USP Dissolution apparatus - I basket should be:
a. Not more than 2.5 m in thickness
b. Not more than 0.1 mm in thickness
c. Not more than 0.025 m in thickness
d. Not more than 0.22 mm in thickness
Q. Which of the following is initial step for drug absorption in case of tablet dosage form?
a. Friability
b. Disintegration
c. Dissolution
d. None of these