Top 150+ Solved Pharmacokinetics MCQ Questions Answer
Q. In which of the model peripheral compartments are connected to a central compartment?
a. Compartment model
b. Caternary model
c. Physiologic model
d. Mammillary model
Q. In which model compartments are joined in series?
a. Compartment model
b. Caternary model
c. Physiologic model
d. Mammillary model
Q. Which of the following is not a characteristic of the caternary compartment model?
a. It gives a visual representation of various rate processes in drug disposition
b. It shows how many rate constants are necessary
c. Compartments and parameters bear a relationship with physiologic functions
d. Useful in predicting drug
Q. In noncompartmental analysis, Mean residence time is equal to _____________
a. The area under the first moment curve/area under the zero moment curve
b. The area under the zero moment’s curve/area under the first moment curve
c. 1 / Area under the first-moment curve
d. 1/ Area under the zero moment curve
Q. Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data?
a. Compartment model
b. Caternary model
c. Physiologic model
d. Mammillary model
Q. Which of the following will be a disadvantage for the physiologic model?
a. Prediction of drug concentration in various body regions
b. Correlation of data in several animal species
c. Obtaining experimental data for each of the organs
d. The model gives an exact description of the drug concentration-time profile for any organ
Q. Which model is also known as membrane permeation rate limited?
a. Physiologic model
b. Compartment model
c. Noncompartment model
d. Mammillary model
Q. What does the word “open” mean in the one compartment open model?
a. The drug easily enters
b. The drug readily mixes with the blood
c. Unidirectional input and output
d. Easy absorption
Q. How much time does an intravenously administered drug take to complete a complete circulation?
a. 5-8 min
b. 7-10 min
c. 1-3 min
d. 1 min
Q. In the equation log C = log Co – KEt/2.303, what does Co stand for _______
a. Plasma drug concentration after 60 min of i.v. injection
b. Plasma drug concentration after 15 min of i.v. injection
c. Plasma drug concentration after 30 min of i.v. injection
d. Plasma drug concentration immediately after i.v. injection.
Q. What is meant by elimination half-life?
a. Time take for half of the amount of drug to get completely eliminated from only the organs
b. Time take for half of the amount of drug to get completely eliminated from only blood
c. Time take for half of the amount of drug to get completely eliminated from only plasma
d. Time take for half of the amount of drug to get completely eliminated from the body as well as plasma
Q. What is the equation to find out the apparent volume of distribution?
a. Amount of drug in the body/plasma drug concentration
b. Plasma drug concentration/amount of drug in the body
c. 1 / plasma drug concentration
d. 1 / Amount of drug in the body
Q. The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?
a. 625 mg/ml
b. 625 l
c. 625 ml
d. 0.0016 mg/ml