Top 150+ Solved Pharmacokinetics MCQ Questions Answer
Q. Parenteral administration:
a. Is too slow for emergency use
b. Cannot be used with unconsciousness patients
c. Generally results in a less accurate dosage than oral administration
d. Usually produces a more rapid response than oral administration
Q. For the calculation of the volume of distribution (Vd) one must take into account:
a. Concentration of substance in urine
b. Therapeutical width of drug action
c. A daily dose of drug
d. Concentration of a substance in plasma
Q. ……….. is a mathematical concept which describes a space in the body which a drug appears tooccupy.
a. Order of reaction
b. Compartment
c. Distribution
d. Elimination
Q. ………………..is the manner in which a drug is taken.
a. Dosage regimen
b. Dosage volume
c. Dosage loading
d. None of the above
Q. …………………it is the extent to which a drug will accumulate relative to the first dose can bequantified by an accumulation factor R.
a. Accumulation Index
b. Apparent volume of drug distribution
c. Accumulation factor
d. None of the above
Q. ………………… is an initial higher dose of a drug that may be given at the beginning of a course oftreatment before dropping down to a lower maintenance dose.
a. Primary Dose
b. Initial Dose
c. Loading dose
d. None of the above
Q. The compartment models provide visual representation of various rate processes involved indrug disposition. Given statement is:
a. False
b. True
c. Cannot say
d. None of the above
Q. ...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid anduniform drug distribution.
a. Central compartment
b. Peripheral compartment
c. both of the above
d. None of the above
Q. ……………composed of groups of tissues with lower blood perfusion and different affinitythe drug with slow drug distribution.
a. Central compartment
b. Peripheral compartment
c. Both of the above
d. None of the above
Q. A multicompartment model assumes that all transfer rate processes for the passage of drug into or outof individual compartments are…………….. processes.
a. First-order
b. Second order
c. Pseudo order
d. None of the above
Q. The multicompartment models are intended to provide…………….
a. Therapeutic activity of the drug
b. Achieve maximum efficacy
c. Both of the above
d. None of the above
Q. The biological half-life of drug:
a. is a constant physical property of the drug
b. is a constant chemical property of the drug
c. may be increased in patients with impaired renal failure
d. may be decreased in patients by giving the drug by rapid I.V. injection
Q. The half life of a drug eliminated by first order elimination kinetics will be longer in individuals whohave an:
a. increased volume of distribution or increased clearance
b. increased volume of distribution or decreased clearance
c. decreased volume of distribution or increased clearance
d. decreased volume of distribution or decreased clearance
Q. Half life (t1/2) is the time required to:
a. change the amount of a drug in plasma by half during elimination
b. metabolize a half of an introduced drug into the active metabolite
c. absorb a half of an introduced drug
d. bind a half of an introduced drug to plasma proteins
Q. Half life (t1/2) does not depend on:
a. biotransformation
b. time of drug absorption
c. concentration of a drug in plasma
d. rate of drug elimination