Top 80+ Solved Metabolism and Endocrinology MCQ Questions Answer

From 76 to 90 of 92

Q. Which of the following does NOT increase intestinal calcium absorption?

a. hypocalcaemia

b. parathyroid hormone (PTH)

c. glucocorticoids

d. hypervitaminosis D

e. protein in diet

  • c. glucocorticoids

Q. Which of the following does NOT stimulate insulin secretion?

a. acetoacetate

b. glucagon

c. hypokalaemia

d. acetylcholine

e. theophylline

  • c. hypokalaemia

Q. Which of the following does NOT decrease intestinal calcium absorption?

a. hypercalcaemia

b. decreased PTH

c. hypovitaminosis D

d. growth hormone

e. phytic acid and oxalate in intestine

  • d. growth hormone

Q. Which of the following does NOT increase plasma calcium?

a. parathyroid hormone

b. vitamin D

c. growth hormone

d. thyroxine

e. calcitonin

  • e. calcitonin

Q. Which of the following is NOT associated with an increase in erythropoietinsecretion?

a. aminophylline

b. renal cell carcinoma

c. cobalt salts

d. thyroxine

e. adenosine

  • a. aminophylline

Q. Regarding erythropoietin, which statement is INCORRECT?

a. its secretion increases within minutes to hours in response to hypoxia

b. it causes pro-erythroblasts to mature more rapidly into erythrocytes

c. the spleen and salivary glands secrete, but don’t synthesise it

d. it inhibits apoptosis in erythroid stem cells

e. the adult liver is able to synthesise enough for normal erythropoiesis in the absence of both kidneys

  • e. the adult liver is able to synthesise enough for normal erythropoiesis in the absence of both kidneys

Q. Which statement regarding parathyroid hormone (PTH) is INCORRECT?

a. it is continuously secreted by the parathyroid glands

b. it is synthesised and secreted by the oxyntic cells

c. it is rapidly cleaved in the Kupffer cells of the liver

d. it increases osteoclasts activity in bone

e. it increases formation of 1,25-dihydroxycholecalciferol

  • b. it is synthesised and secreted by the oxyntic cells

Q. Regarding endothelins, which statement is INCORRECT?

a. they can cause dose-dependent vasoconstriction in most vascular beds

b. they activate phospholipase C

c. they are structurally similar to vasoactive intestinal contractor

d. they have negative inotropic effect

e. there are low concentrations present in blood

  • d. they have negative inotropic effect

Q. Which statement regarding calcitonin is INCORRECT?

a. it is secreted by parafollicular cells of the thyroid gland

b. it inhibits osteoclastic bone resorption

c. total thyroidectomy is usually associated with hypercalcaemia

d. it decreases renal tubular calcium and phosphate reabsorption

e. it is only secreted when plasma calcium concentration exceeds 9.5mg/100ml

  • c. total thyroidectomy is usually associated with hypercalcaemia

Q. Regarding atrial natriuretic peptide, which statement is INCORRECT?

a. cardiac innervation is not required for secretion to occur

b. its action is terminated by receptor-mediated endocytosis

c. its filtration fraction is decreased

d. it is secreted by heart, lung and brain

e. glucocorticoids increase its secretion

  • c. its filtration fraction is decreased

Q. Regarding the role of vitamin D in calcium metabolism, which of the following isINCORRECT?

a. it increases renal tubular calcium and phosphate reabsorption

b. it causes an increase in synthesis of calcium-binding protein

c. it increases bone resorption

d. it decreases bone formation

e. it increases intestinal calcium and phosphate absorption

  • d. it decreases bone formation

Q. Atrial natriuretic peptide decreases formation of all of the following EXCEPT:

a. aldosterone

b. cyclic GMP

c. renin

d. vasopressin

e. angiotensin III

  • b. cyclic GMP

Q. Which of the following does NOT increase aldosterone secretion?

a. constriction of the IVC in the thorax

b. ACTH

c. surgery

d. hyperkalaemia

e. lying supine from the standing position

  • e. lying supine from the standing position

Q. Regarding aldosterone, which statement is INCORRECT?

a. it responds to changes in plasma sodium more strongly than changes in plasma potassium

b. it is only synthesised in the zona glomerulosa of the adrenal cortex

c. its main action is to increase the synthesis of sodium-potassium pumps

d. angiotensins II and III have about equal mineralocorticoid stimulating activity

e. it acts via a cytoplasmic receptor that has equal affinity for cortisol

  • a. it responds to changes in plasma sodium more strongly than changes in plasma potassium
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