Top 80+ Solved Metabolism and Endocrinology MCQ Questions Answer
Q. Uric acid handling by the kidneys involves:
a. filtration only
b. secretion by tubules only
c. filtration and secretion
d. filtration and reabsorption
e. filtration, reabsorption and secretion
Q. With regard to the metabolism of carbohydrates:
a. in the absence of liver glycogen stores, glycogen administration does not cause hyperglycaemia
b. glucocorticoids have a minor effect on gluconeogenesis
c. growth hormone causes increased use of glucose for energy
d. glucose is absorbed by most cells by active sodium glucose co-transport
e. during starvation, stores last for less than 24 hours
Q. With regard to lipid metabolism:
a. only HDL is formed in the liver
b. fatty acids in the plasma form 1:1 complexes with albumin
c. plasma cholesterol levels rise considerably with an increase in daily ingestion
d. free fatty acids are metabolised in preference to glucose in a non-exercising individual
e. utilisation of fatty acids is stimulated by glucocorticoids
Q. With regard to carbohydrate metabolism:
a. the normal fasting glucose is from 3.9 to 11.0mmol/L
b. glucose is phosphylated in cells to glucose-6-phosphate by phosphoenol-pyrunate carboxykinase
c. glycogen, the storage form of glucose, is only in the liver and skeletal muscle
d. glucose can be converted to fats through acetyl CoA which is irreversible
e. none of the above
Q. Which statement regarding glucagon is INCORRECT?
a. it is used as an antidote in symptomatic beta blocker overdosage
b. it is synthesised in the A cells of the pancreatic islets and in small intestinal mucosal cells
c. its major site of metabolism is in the plasma
d. it is synthesised in common with glicentin
e. the exogenous glucagon is associated with nausea and vomiting
Q. Which of the following is NOT an action of somatostatin?
a. it inhibits glucagon secretion
b. it is a synaptic transmitter in the retina
c. it inhibits insulin secretion
d. it increases contraction of the gallbladder
e. it inhibits pancreatic polypeptide secretion
Q. Glucagon increases the secretion of all of the following EXCEPT:
a. catecholamines from a phaeochromocytoma
b. atrial natriuretic peptide
c. growth hormone
d. insulin
e. calcitonin from a medullary carcinoma of the thyroid
Q. Regarding the actions of glucagon, which of the following is INCORRECT?
a. it increases blood lactate level
b. it activates hormone-sensitive lipase
c. it has a positive inotropic effect on myocardium
d. large amounts cause intestinal relaxation
e. it decreases renal tubular sodium reabsorption
Q. Which of the following does NOT increase pancreatic polypeptide secretion?
a. protein ingestion
b. fasting
c. exercise
d. acute hypoglycaemia
e. intravenous glucose
Q. Which iodinated compound is present in GREATEST amounts in the adult thyroidgland?
a. T4
b. DIT
c. MIT
d. T3
e. RT3
Q. Regarding the action of glucagon on the liver, which of the following is INCORRECT?
a. it causes glycogenolysis via activation of adenylate cyclase
b. it decreases metabolism of glucose-6-phosphate
c. it causes glycogenolysis via activation of phospholipase C
d. it increases gluconeogenesis from available amino acids
e. it decreases ketone body formation
Q. Regarding the synthesis of thyroid hormones, which statement is INCORRECT?
a. iodine undergoes rapid oxidation following entry to thyroid cells
b. the “iodine pump” is the major source of iodine for hormone synthesis
c. TSH increases iodine uptake by the thyroid gland
d. thiocyanate and ouabain decrease iodine uptake by the thyroid gland
e. it involves iodination of thyrosine residues in thyroglobulin
Q. Regarding insulin, which statement is INCORRECT?
a. it consists of two polypeptide chains linked by two disulphide bridges
b. the majority of exogenous insulin is metabolised by the liver
c. it is not the only molecule responsible for insulin-like activity in the blood
d. it increases intracellular potassium concentration
e. exercise increases the affinity of its receptors for insulin
Q. Which iodinated compound is present in the SMALLEST amounts in the adult thyroidgland?
a. T4
b. DIT
c. MIT
d. T3
e. RT3