Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. Which drug easily bind to AAG?
a. Cationic drug
b. Anionic drug
c. Lipophilic drug
d. Neutral drug
Q. The extent of drug-protein binding can change with both changes in protein and drug concentration.
a. True
b. False
c. none
d. all
Q. In the equation X= Vd C, what does X stands for?
a. Amount of drug in the blood
b. Amount of drug in plasma
c. Amount of drug in the tablet
d. Amount of drug in the body
Q. Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
a. True
b. False
c. none
d. all
Q. Displacement interactions are significant in the case of drugs which are more than 95% bound.
a. True
b. False
c. none
d. all
Q. The value of association constant, Ka and the number of binding sites N can be obtained by
a. Direct plot
b. Scatchard plot
c. Klotz plot
d. All of the above
Q. What is interaction of phenobarbitone and warfarin?
a. Displacement of warfarin from binding site
b. Decreased absorption of warfarin
c. Increase metabolism of warfarin
d. Decreased metabolism of warfarin
Q. Which process involves alteration of drug distribution?
a. Competitive binding
b. Reduced plasma protein level
c. Both
d. None
Q. Two most common protein involved in plasma protein binding are
a. Globulin and plasmin
b. Albumin and globulin
c. Fibrin and globulin
d. Plasmin and fibrin
Q. All of the following displace imipramine from protein binding site except
a. Aspirin
b. Phenytoin
c. Ethosuximide
d. Phenylbutazone
Q. The drugs which are most affected in pregnancy are those having
a. Low protein binding and high Vd
b. High protein binding and low Vd
c. High protein binding and high Vd
d. Low protein binding and low Vd
Q. Most of drugs will bind with which of plasma protein
a. Albumin
b. Globulin
c. Histone
d. Glycoprotein
Q. Which of the following is not highly protein bound drug
a. Barbiturates
b. Phenylbutazone
c. Salicylates
d. Aspirin