Top 350+ Solved Biopharmaceutics and Pharmacokinetics MCQ Questions Answer
Q. For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximumclearance is approximately
a. 1-2 milliliters/min
b. 12 milliliters/min
c. 120 milliliters/min
d. 1200 milliliters/min
Q. Elimination is expressed as follows:
a. Rate of renal tubular reabsorption
b. Clearance speed of some volume of blood from substance
c. Time required decreasing the amount of drug in plasma by one-half
d. Clearance of an organism from a xenobiotic
Q. ………….drug shows active tubular secretion.
a. Penicillin
b. Tetracycline
c. Indomethacine
d. None of the above
Q. Which tissue has the greatest capacity to biotransform of drugs?
a. Kidney
b. Lung
c. Liver
d. Skin
Q. The process in which some drugs stimulate their own metabolism is known as
a. Enzyme inhibition
b. Autoinduction
c. Product inhibition
d. None of the above
Q. Drugs undergoing first pass metabolism are advised not to be administered through
a. Rectal
b. Oral
c. Transdermal
d. Parenteral
Q. ………..is defined as volume of blood or plasma from drug is removed in unit time
a. half life
b. clearance
c. volume of distribution
d. biotr
Q. Tubular reabsorption is achieved by……………
a. active process
b. passive process
c. Both (a) & (b)
d. none of the above
Q. Below mentioned all factors increases plasma elimination half life except
a. Higher protein binding
b. Higher tissue binding
c. Higher apparent Vd
d. Higher ratio renal / hepatic clearance
Q. Hepatic excretion of drug with high extraction ratio is altered by
a. Protein binding
b. Blood flow
c. both (a) & (b)
d. None of the above
Q. The phenomenon of decreased drug metabolizing ability of the enzymes by drugs is known as……………
a. enzyme induction
b. enzyme inhibition
c. both (a) & (b)
d. None of the above
Q. Active tubular reabsorption of drug depends on………………
a. pH of urine
b. urine flow rate
c. pKa of drug
d. all of the above
Q. Which of the following is not a factor of renal excretion?
a. Blood flow to the kidneys
b. Urine pH
c. Blood pH
d. Disease state
Q. Which of the following is not a physicochemical factor of drug that can affect the renal excretion?
a. Molecular size
b. Disintegration rate
c. pKa of the drug
d. Lipid solubility
Q. Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus.
a. True
b. False
c. none
d. all