Top 250+ Solved Absorption MCQ Questions Answer
Q. In the equation G=Ki (Cs-Cb), what does G stands for______________
a. Dissolution rate per unit area
b. Effective interfacial transport constant
c. Concentration of the solute
d. Concentration of the impurity
Q. Which model does not approve the existence of the stagnant layer in the solid-liquid interface?
a. Interfacial barrier model
b. Diffusion layer model
c. Penetration or surface renewal theory
d. Danckwert’s model
Q. What does the interfacial barrier model states?
a. An intermediate concentration exists at the interface
b. Turbulence in the dissolution medium exists at the solid/liquid interface
c. Formation a thin film or layer at the solid-liquid interface
d. Solutes passes easily through the interfaces
Q. In the equation, Wo1/3-W1/3=Kt, K stands for ____________
a. The original mass of the drug
b. Mass of the drug remaining after time t
c. Dissolution constant
d. Concentration of solute
Q. Which are the two rate-determining step of drug absorption when given orally?
a. Disintegration and deaggregation
b. Disintegration and Dissolution
c. Dissolution and permeation through the membrane
d. Permeation through the membrane and Disintegration
Q. The maximum amount of solute dissolved in a given solvent under standard conditions of temperature, pressure, and pH is known as __________
a. Dissolution rate
b. Intrinsic dissolution
c. Rate limiting step
d. Absolute or intrinsic solubility
Q. Which option will be the best example of the physicochemical properties of drugs?
a. Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability, pH, Pressure of disintegration
b. Pressure of disintegration, polymorphism, salt form, pseudo polymorphism, complexation, wettability, pH
c. Solubility, particle size, polymorphism, salt form
d. Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability
Q. For oral formulation, what should be the minimum aqueous solubility to avoid bioavailabilityproblems?
a. 0.9%
b. 1%
c. 2%
d. 0.11%
Q. The total solid surface area of any particle is known as ___________
a. Absolute surface area
b. Effective surface area
c. Total surface area
d. Surface area
Q. Particle size and surface area of a drug are directly related to each other.
a. True
b. False
c. none
d. all
Q. Absolute surface area is proportional to the dissolution rate of a drug.
a. True
b. False
c. none
d. all
Q. In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement?
a. The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability
b. The particles reaggregate to form larger particles due to their high surface free energy
c. Extreme reduction in the particle size imparts surface charges that may prevent wetting
d. Extreme reduction in the size brings the hydrophobic amino acids to the surface
Q. How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?
a. Use of surfactant
b. Use of Hydrophobic diluents
c. Use of surfactant and hydrophilic diluents
d. No need of doing micronization