Top 250+ Solved Absorption MCQ Questions Answer
Q. What should be the range of oil/water partition coefficient of any drug?
a. 1-2
b. 3-4
c. 2-3
d. 1-3
Q. Ibuprofen a weak acid, in the stomach will be present in which of the given form?
a. Ionized form mostly
b. Non-ionized form mostly
c. Half ionized and half no ionized
d. Will form aggregate
Q. Nitrazepam a weak base, will be in which form in the stomach?
a. Ionized form mostly
b. Non-ionized form mostly
c. Half ionized and half no ionized
d. Will form aggregate
Q. All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.
a. True
b. False
c. none
d. all
Q. Heroin with pKa 7.8 will be in which form in intestinal pH?
a. Ionized form mostly
b. Unionized form mostly
c. Half ionized and half no ionized
d. Will form aggregate
Q. Which one of these options is not one of the limitations of pH-partition theory?
a. Presence if virtual membrane pH
b. Absorption of ionized drugs
c. Influence of GI surface area
d. Dissolution rate
Q. A microclimate pH, different from the luminal pH exists at the membrane surface.
a. True
b. False
c. none
d. all
Q. According to the pH-partition theory which form of the drug gets absorbed mostly?
a. Hydrated form
b. Aggregated form
c. Ionised
d. Unionised
Q. What helps the ionized drug molecules to pass through the cell membrane passively?
a. Different pH
b. Polar group
c. Large lipophilic group
d. Hydration
Q. Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through theintestine.
a. True
b. False
c. none
d. all
Q. What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?
a. More surface area
b. Long residence time
c. Large surface area and long residence time
d. Large surface area, long residence time, basic pH
Q. What are the major stability problems which result in poor bioavailability of any orally administereddrugs?
a. Acidic degradation
b. Degradation by salivary amylase
c. Degradation of the drug in inactive form
d. Interaction with the excipients and degradation in an inactive form
Q. The entire length of the GI is lined by ___________
a. Blood vessels
b. Nerves
c. Mucopolysaccharides
d. No lining direct contact with the cell