Top 50+ Solved Protein Binding of Drugs MCQ Questions Answer
Q. Which of the following factors for protein drug binding is a drug interaction factor?
a. Competition between drugs for the binding site
b. Age
c. Physicochemical characteristics of a drug
d. Physicochemical characteristics of the protein or binding agent
Q. Which drugs bind to HSA easily?
a. Cationic drug
b. Anionic drug
c. Lipophilic drug
d. Neutral drug
Q. Which drugs easily bind to adipose tissue?
a. Cationic drug
b. Anionic drug
c. Lipophilic drug
d. Neutral drug
Q. Which drug easily bind to AAG?
a. Cationic drug
b. Anionic drug
c. Lipophilic drug
d. Neutral drug
Q. The extent of drug-protein binding can change with both changes in protein and drug concentration.
a. True
b. False
c. none
d. all
Q. In the equation X= Vd C, what does X stands for?
a. Amount of drug in the blood
b. Amount of drug in plasma
c. Amount of drug in the tablet
d. Amount of drug in the body
Q. Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
a. True
b. False
c. none
d. all
Q. Displacement interactions are significant in the case of drugs which are more than 95% bound.
a. True
b. False
c. none
d. all
Q. The value of association constant, Ka and the number of binding sites N can be obtained by
a. Direct plot
b. Scatchard plot
c. Klotz plot
d. All of the above
Q. What is interaction of phenobarbitone and warfarin?
a. Displacement of warfarin from binding site
b. Decreased absorption of warfarin
c. Increase metabolism of warfarin
d. Decreased metabolism of warfarin
Q. Which process involves alteration of drug distribution?
a. Competitive binding
b. Reduced plasma protein level
c. Both
d. None
Q. Two most common protein involved in plasma protein binding are
a. Globulin and plasmin
b. Albumin and globulin
c. Fibrin and globulin
d. Plasmin and fibrin
Q. All of the following displace imipramine from protein binding site except
a. Aspirin
b. Phenytoin
c. Ethosuximide
d. Phenylbutazone