Top 550+ Solved Physiology MCQ Questions Answer

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Q. 85% of NaHCO3 in the filtrate is reabsorbed in the:

a. proximal convoluted tubule

b. descending loop of Henle

c. thick ascending loop of Henle

d. distal convoluted tubule

e. collecting ducts

  • a. proximal convoluted tubule

Q. Thiazide diuretics exert their main effect in the:

a. proximal convoluted tubule

b. descending loop of Henle

c. thick ascending loop of Henle

d. distal convoluted tubule

e. collecting ducts

  • d. distal convoluted tubule

Q. Ethacrynic acid exerts its principle effect in the:

a. proximal convoluted tubule

b. descending loop of Henle

c. thick ascending loop of Henle

d. distal convoluted tubule

e. collecting ducts

  • c. thick ascending loop of Henle

Q. When considering fluid balance, which of the following is INCORRECT?

a. the minimum daily fluid output may normally be estimated by measuring the urine output and adding 500ml

b. urine output is always the single largest contributor to fluid output

c. fluid intake and output may be altered in response to a change in extracellular osmolarity

d. fluid intake and output may be altered in response to a change in extracellular volume

e. the hypothalamus is an important regulator of fluid intake

  • b. urine output is always the single largest contributor to fluid output

Q. Which of the following does NOT stimulate erythropoietin secretion?

a. cobalt salts

b. thromboxanes

c. androgens

d. adenosine

e. prostaglandins

  • b. thromboxanes

Q. Glomerular filtration rate is best measured using:

a. inulin

b. glucose

c. PAH

d. urea

e. creatinine

  • a. inulin

Q. “Renal dose” dopamine increases glomerular filtration rate by:

a. dilating the renal arteries

b. dilating the vasa recta

c. constricting the efferent arteriole

d. relaxing glomerular perivascular mesangial cells

e. all of the above

  • d. relaxing glomerular perivascular mesangial cells

Q. Regarding the kidney:

a. the glomerular filtration rate is 125mls/hr

b. the renal threshold for glucose 300mg/dL

c. glucose transport is an example of secondary active transport

d. the blood flow in the renal medulla is greater than in renal cortex

e. a high protein diet decreases renal blood flow

  • c. glucose transport is an example of secondary active transport

Q. Which of the following substances is not excreted by the kidney in a normal adult on an average diet?

a. K+

b. uric acid

c. creatinine

d. glucose

e. urea

  • d. glucose

Q. Which of the following statements regarding erythropoietin is INCORRECT in an adult?

a. half-life of about 5 hours

b. hypoxia can increase secretion within minutes

c. is secreted by spleen and salivary glands

d. is secreted in adequate amounts by liver in absence of kidneys

e. is a glycoprotein

  • d. is secreted in adequate amounts by liver in absence of kidneys

Q. “Renal dose” dopamine is:

a. 1-2 mcg/kg/min

b. 1-5 mcg/kg/min

c. 1-10 mcg/kg/min

d. 1-20 mcg/kg/min

e. greater than 20 mcg/kg/min

  • d. 1-20 mcg/kg/min

Q. Frusemide acts as a diuretic primarily by:

a. inhibiting Na+ /K+ /Cl- co-transport in loop of Henle

b. inhibiting action of vasopressin on collecting duct

c. decreasing H+ secretion with resultant increase in Na+/K+ excretion

d. inhibiting vasopressin secretion

e. inhibiting Na+/K+ exchange in collecting ducts by inhibiting the action of aldosterone

  • a. inhibiting Na+ /K+ /Cl- co-transport in loop of Henle

Q. Regarding the osmolality of renal tubular fluid, is it?

a. hypotonic in loop of Henle

b. isotonic in proximal tubule

c. hypertonic in distal tubule

d. hypotonic in collecting duct

e. hypotonic in proximal tubule

  • b. isotonic in proximal tubule

Q. Which of the following statements regarding renal tubular glucose absorption isINCORRECT?

a. binds to SGLT-2 in luminal membrane

b. example of secondary active transport

c. transported out of luminal cell by GLUT-2

d. about 100% reabsorption in proximal tubule if less than transport maximum

e. linked to sodium reabsorption

  • a. binds to SGLT-2 in luminal membrane

Q. Which of the following does NOT increase renal tubular sodium reabsorption?

a. cortisol

b. oestrogen

c. growth hormone

d. insulin

e. glucagon

  • e. glucagon
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