Top 150+ Solved Pharmacology MCQ Questions Answer

a. Most penicillins only cross the blood brain barrier when the meninges are inflamed.

b. Penicillins don’t require dosage adjustment in renal failure

c. Penicillins inhibit cross linkage of peptidoglycans in the cell wall

d. Piperacillin is a penicillin active against pseudomonas

e. Only about 5 to 10% of people with a past history of penicillin allergy have a reaction on re exposure

a. Is a defluorinated analogue of nalidixic acid

b. Inhibits tropoisomerases 2 and 3

c. Has no gram positive cover

d. Has a bioavailability of 30%

e. May cause an arthropathy

a. Can be due to an efflux pump

b. Is most commonly due to modification of the target PBPs

c. Does not involve penetration of drug to target PBPs

d. Infers resistance only to penicillinc

e. Can involve up to 5 different B lactamases

a. Have enhanced activity at acidic pH

b. Have little activity against legionella

c. Have half lives which increase in patients with anuria

d. Induce cytochrome p450 enzymes

e. Are contraindicated in neonates

a. Is ineffective against streptococci

b. Is active against enterococci and anaerobes

c. Blocks transpeptidation and inhibits peptidoglycan synthesis

d. Is poorly absorbed orally

e. Has excellent penetration into CNS and prostate

a. Norfloxacillin

b. Chloramphenicol

c. Trimethoprim

d. Rifampicin

e. Sulfasalazine

a. Cefaclor

b. Ceftazidime

c. Cephalexin

d. Cefotaxime

e. Cephalothin

a. Tetracyclines are 40 to 80 % bound by serum proteins

b. Absorption is enhanced by coadministration of antacids

c. Tetracyclines cross the blood brain barrier easily

d. Doxycycline is excreted predominantly by the kidney

e. Demeclocyline is a short acting tetracycline drug

a. Hepatitis

b. Peripheral neuropathy

c. Retrobulbar neuritis

d. Decreased phenytoin metabolism – increased phenytoin blood levels / toxicity

e. CNS toxicity

a. 90% of vancomycin is excreted by glomerular filtration

b. Inhibits proteinsynthesis in bacteria

c. Is bactericidal against gram negative bacilli

d. Is well absorbed from the GIT

e. One adverse reaction to infusions of vancomycin is the “blue man” syndrome

a. blockage of viral uncoating is caused by rifampicin

b. Zidovudine is a protease inhibitor

c. Amantidine blocks viral DNA packaging and assembly

d. Indinavir is a reverse transcriptase inhibitor

e. Acyclovir inhibits viral DNA synthesis

a. Enamel dysplasia is common with aminoglycosides

b. Gray baby syndrome occurs with rifampicin use

c. Haemolytic anaemias can occur with sulphonamide use

d. Nephritis is the most common adverse reaction with isoniazid

e. Disulfiram like reaction can occur with macrolides

a. Does not penetrate the blood brain barrier

b. Must be administered parenterally

c. Can be safely used in premature infants

d. Can cause depression of bone marrow function

e. Can cause discoloration of developing teeth when given to children

a. Has a steroid structure

b. Is a partial agonist

c. Promotes sodium retention

d. Increases potassium loss

e. Is a loop diuretic

a. Ethanol – by preventing the reabsorption of sodium from renal tubular fluid

b. Digoxin – by inhibiting release of ADH

c. Dopamine – by inhibiting active transport of chloride over the entire length of the descending limb of the loop of Henle

d. Frusemide – by inhibiting carbonic anhydrase

e. Chlorothiazide – by inhibiting active sodium transport in the ascending limb of the loop of Henle