Top 150+ Solved Pharmacology MCQ Questions Answer

From 46 to 60 of 113

Q. Suxamethonium

a. Is a non-depolarising neuromuscular blocking agent

b. Is contraindicated in all eye operations

c. Stimulates cardiac muscarinic receptors and autonomic ganglia

d. Its action is directly terminated by the action of plasma cholinesterase

e. Should not be administered to patients with burns >24 hours old because of its hypercalcaemic effect

  • c. Stimulates cardiac muscarinic receptors and autonomic ganglia

Q. Inhalational anaesthetics

a. Enflurane is proconvulsant

b. Isoflurane is the inhalational agent of choice in patients with active IHD

c. Nitrous oxide is a useful adjunct to volatile anaesthetic use in women in the first trimester of pregnancy

d. Halothane has a MAC value of 75% making it less potent than desflurane

e. Desflurane is extensively metabolised via the liver

  • a. Enflurane is proconvulsant

Q. Phenytoin

a. Is 20-30% bound to albumin

b. Is the drug treatment of choice in absence seizures

c. Undergoes flow limited elimination

d. Steady state mean plasma concentrations varies disproportionately with the dose

e. Preferentially binds to activated state sodium channels

  • d. Steady state mean plasma concentrations varies disproportionately with the dose

Q. Drugs of abuse can be extremely dangerous in the wrong hands! Which of the following is correct

a. Ketamine is structurally related to psilocybin

b. LSD acts on various 5 HT receptor subtypes to produce its mind altering effects

c. Marijuana causes mydriasis and conjunctival infection

d. Cocaine has a long plasma half life

e. Amphetamine like drugs cause marked stimulation of appetite

  • b. LSD acts on various 5 HT receptor subtypes to produce its mind altering effects

Q. Flumazenil

a. Is cleared renally

b. Predictably reverses benzodiazepine induced respiratory depression

c. Antagonises CNS effects of opioids

d. Can precipitate seizures in mixed overdose

e. Has a half life of around 10 hours

  • d. Can precipitate seizures in mixed overdose

Q. Regarding non-depolarising muscle relaxants

a. Pancuronium is eliminated via the kidney

b. Roacuronium is an isoquinolone derivative

c. Roacuronium undergoes Hoffman elimination

d. Vecuronium is eliminated predominantly via the kidney

e. Atracurium is eliminated via plasma pseudocholinesterase

  • a. Pancuronium is eliminated via the kidney

Q. Which of the following is a direct serotonin agonist

a. Fluoxetine

b. Amitriptylline

c. Moclobemide

d. Ondansetron

e. Sumatriptan

  • e. Sumatriptan

Q. The opiate associated with seizures when given in high doses to patients with renal failure is

a. Morphine

b. Pethidine

c. Methadone

d. Fentanyl

e. Codeine

  • b. Pethidine

Q. Which of the following local anaesthetic agents is an ester

a. Bupivacaine

b. Ropivacaine

c. Prilocaine

d. Procaine

e. Lignocaine

  • d. Procaine

Q. Regarding temazepam – all of the following are true EXCEPT

a. It produces inactive metabolites

b. It induces enzymes only to a minimal extent

c. It causes less hangover than nitrazepam

d. It causes rebound insomnia

e. It increases REM sleep

  • e. It increases REM sleep

Q. Regarding the antiepileptic drugs

a. Lorazepam has documented efficacy against absence seizures

b. Phenytoin is able to stimulate its own metabolism by enzyme induction

c. Valproate has a large Vd (>500l/70kg)

d. The most common dose related adverse effects of Carbamazepine are ataxia and diplopia

e. Vigabatrin works by sodium channel blockade

  • d. The most common dose related adverse effects of Carbamazepine are ataxia and diplopia

Q. Regarding drugs used in Parkinson’s disease

a. Bromocriptine is the first line drug to treat Parkinson’s disease in psychotic patients

b. 80-90% of a single dose of Levodopa enters the brain unaltered

c. Patients taking Selesiline to treat Parkinson’s disease are limited in what they can eat because of the tyranine reaction phenomenon

d. Amantadine has anti Parkinsonian effects and is administered at a dose of 100mg bd

e. Anti muscarinic drugs are of benefit in elimination of bradykinesia in Parkinson’s

  • d. Amantadine has anti Parkinsonian effects and is administered at a dose of 100mg bd

Q. A patient complains of post op muscle pain. This is most likely to be due to

a. Suxamethonium

b. Propofol

c. Isoflurane

d. Atracurium

e. Ketamine

  • a. Suxamethonium

Q. Lithium

a. Has rapid onset of action

b. Is partially renally excreted

c. Has no neurological side effects

d. Has no contraindications to be given in conjunction with NSAIDS

e. Is contraindicated in sick sinus syndrome

  • e. Is contraindicated in sick sinus syndrome

Q. With respect to opioid receptors

a. Fentanyl works predominantly at the kappa receptors

b. Both U and delta receptors contribute to respiratory depression

c. Methadone is used for heroin withdrawal because its actions are predominantly at the delta receptors

d. Opioid receptors are coupled to a tyrosine kinase mechanism of action

e. Physical dependence and tolerance is caused by the rapid disintegration of receptors

  • b. Both U and delta receptors contribute to respiratory depression
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