Top 150+ Solved Pharmacology MCQ Questions Answer
Q. Regarding antiseptic agents – all of the following are true EXCEPT
a. Sodium hypochlorite is an effective antiseptic for intact skin
b. Potassium permanganase is an effective bactericidal agent
c. Formaldehyde may be used to disinfect instruments
d. Chlorhexidine is active against gram positive cocci
e. Ethanol is an effective skin antiseptic because it denatures microbial proteins
Q. Ciprofloxacin
a. Is a defluorinated analogue of nalidixic acid
b. Inhibits tropoisomerases 2 and 3
c. Has no gram positive cover
d. Has bioavailability of 30%
e. May cause an arthropathy
Q. Ribosomal resistance occurs with
a. Sulphonamides
b. Penicillin
c. Fluoroquinolones
d. Macrolides
e. Trimethoprim
Q. Regarding antivirals
a. Delvindine is a nucleoside reverse transcriptase inhibitor (NRTI)
b. Zidovudine (AZT) is a non nucleoside reverse transcriptase inhibitor (NNRTI)
c. NRTIs activate HIV-1 reverse transcriptase
d. Abacavir is a protease inhibitor
e. NRTIs require intracytoplasmic activation to the triphosphate form
Q. All of the following are true regarding metronidazole EXCEPT
a. It is used to treat giardia
b. It causes a metallic taste in the mouth
c. It inhibits alcohol dehydrogenase
d. It is used to treat gardnerella
e. It is useful against trichomonoas vaginalis
Q. Regarding antipsychotics as a group
a. Metabolites are important to the action of these drugs
b. Haloperidol has a higher systemic availability than thioridazine or chlorpromazine
c. Elimination half lives of these drugs range between 3 – 6 hours
d. This group of drugs generally has short clinical duration of action
e. Clozipine is a member of the dihydroindolone group
Q. Which of the following antipsychotics (in excess dose) is responsible forcardiac arrhythmias?
a. Chlorpromazine
b. Clozapine
c. Thioridazine
d. Haloperidol
e. Thiothixene
Q. Plasma lithium levels (assuming no change in daily lithium dose) may become toxic in the presence of all of the following EXCEPT
a. Pregnancy
b. Use of thiazides
c. Dehydration
d. Use of some non-steroidal anti-inflammatory drugs
e. Post partum state
Q. Regarding pharmacokinetics of antidepressants
a. Most are highly protein bound
b. Fluoxetine is poorly absorbed
c. Tricyclics are predominantly excreted unchanged in the urine
d. Plasma half lives of antidepressants are mostly less than 10 hours
e. The half life of the older MAOIs is helpful in governing doses
Q. Which of the following drugs is potentially dangerous in a single drug overdose
a. Moclobemide
b. Paroxetine
c. Sertraline
d. Trazodone
e. Amoxapine
Q. Which of the following drugs is 99% protein bound in plasma
a. Gentamicin
b. Theophylline
c. Carbamazepine
d. Atenolol
e. Diazepam
Q. Which of the following drugs is contraindicated (absolutely) in a patient with porphyria
a. Zolpidem
b. Chloral hydrate
c. Buspirone
d. Phenobarbitone
e. Diazepam
Q. Regarding local anaesthetic agents
a. Lignocaine is also an antiarrhythmic of the Vaughan Williams classification group 1A
b. At normal pH the larger fraction of local anaesthetic in the body fluids will be in the unchanged form
c. Bupivacaine may cause an apparent cyanosis in some patients
d. The duration of action of procaine will be increased in the presence of liver disease
e. Local anaesthetic agents block conduction in small myelinated axons prior to blockade of other axons
Q. Regarding IV anaesthetic agents
a. Ketamine is the induction agent of choice in a head injured patient
b. Propofol has a slow offset of action
c. Etomidate causes hypotension more commonly than thiopentone
d. Ideal agents for neuroleptanalgesia are fentanyl and droperidol
e. Thiopentone is metabolised at a rate of 40-50% per hour in humans following a single dose