Top 550+ Solved Physiology MCQ Questions Answer

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Q. Regarding jugular pressure waves:

a. the ‘v’ wave denotes the increased atrial pressure due to the bulging of the tricuspid valve during isovolumetric ventricular contraction

b. in tricuspid insufficiency, there is a giant ‘A’ wave with each ventricular systole

c. atrial premature beats produce an ‘A’ wave

d. the ‘v’ wave occurs during systole

e. a giant ‘C’ wave (‘cannon wave’) may be seen in complete heart block

  • c. atrial premature beats produce an ‘A’ wave

Q. What factor does not alter cardiac output?

a. standing up

b. sleeping

c. eating

d. exercising

e. pregnancy

  • b. sleeping

Q. What is the O2 consumption of a beating heart at rest?

a. 2ml/100g/min

b. 9ml/g/min

c. 2ml/g/min

d. 2L/100g/min

e. 9ml/100g/min

  • e. 9ml/100g/min

Q. Regarding percentages of blood volume in the body:

a. the heart has 5%

b. the pulmonary circulation has the greatest percentage

c. the venous circulation has 35%

d. the aorta has 2%

e. capillaries have 20%

  • d. the aorta has 2%

Q. What is a biological action of endothelin?

a. dilates vascular smooth muscle

b. produces bronchodilation

c. increase GFR and renal blood flow

d. evokes positive inotropic and chronotropic effects on myocardium

e. inhibits gluconeogenesis

  • d. evokes positive inotropic and chronotropic effects on myocardium

Q. What inhibits gene transcription for endothelin-1 secretion:

a. nitric oxide

b. angiotensin II

c. insulin

d. growth factors

e. catecholamines

  • a. nitric oxide

Q. Regarding NO synthase:

a. it synthesises nitrous oxide from arginine

b. there are 2 isoforms

c. it is inactivated by haemoglobin

d. NOS-1 is activated by cytokines

e. NOS-2 is in endothelial cells

  • c. it is inactivated by haemoglobin

Q. What factor dilates the arterioles?

a. decreased local temperature

b. myogenic theory of autoregulation

c. angiotensin II

d. increased discharge of noradrenergic vasomotor nerve

e. histamine

  • e. histamine

Q. Which is NOT a baroreceptor site?

a. right atria at the entrance of SVC and IVC

b. aortic arch

c. left atria at the entrance of the pulmonary veins

d. pulmonary circulation

e. carotid body

  • e. carotid body

Q. Regarding the synthesis of thyroid hormones, which statement is INCORRECT?

a. iodine undergoes rapid oxidation following entry to thyroid cells

b. the “iodine pump” is the major source of iodine for hormone synthesis

c. TSH increases iodine uptake by the thyroid gland

d. thiocyanate and ouabain decrease iodine uptake by the thyroid gland

e. it involves iodination of thyrosine residues in thyroglobulin

  • b. the “iodine pump” is the major source of iodine for hormone synthesis

Q. Regarding insulin, which statement is INCORRECT?

a. it consists of two polypeptide chains linked by two disulphide bridges

b. the majority of exogenous insulin is metabolised by the liver

c. it is not the only molecule responsible for insulin-like activity in the blood

d. it increases intracellular potassium concentration

e. exercise increases the affinity of its receptors for insulin

  • b. the majority of exogenous insulin is metabolised by the liver

Q. Which of the following hormones does NOT increase the hepatic output of glucose?

a. growth hormone

b. adrenaline

c. glucagon

d. noradrenaline

e. cortisol

  • a. growth hormone

Q. Which thyroid hormone has the longest plasma half-life?

a. T4

b. DIT

c. MIT

d. T3

e. RT3

  • a. T4

Q. Regarding the action of insulin on adipose tissue, which of the following isINCORRECT?

a. it induces lipoprotein lipase which actively hydrolyses triglyceride from circulating lipoproteins

b. it reduces circulating free fatty acids

c. it promotes triglyceride storage in adipocytes

d. it directly inhibits intracellular lipase

e. its effects appear to involve phosphorylation of lipases

  • e. its effects appear to involve phosphorylation of lipases
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