Top 550+ Solved Physiology MCQ Questions Answer

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Q. Mono-iodotyrosin (MIT) and diiodotyrosin (DIT) molecules:

a. are deiodinated before joining to form T3 and T4

b. are secreted into plasma alongside T3 and T4

c. are the inactive metabolites of T3 and T4

d. are cleaved from thyroglobulin by proteases in lysosomes

e. are usually excreted in the urine

  • d. are cleaved from thyroglobulin by proteases in lysosomes

Q. Calcitonin secretion is stimulated by the following EXCEPT:

a. gastrin

b. somatostatin

c. oestrogen

d. cholecystokinin

e. glucagon

  • b. somatostatin

Q. With regard to gastric acid secretion, all the following are true EXCEPT:

a. acetylcholine stimulates secretion

b. both G protein and direct calcium channels are involved

c. an H+ - K+ antiport transports H+ into the gastric lumen

d. parietal cells have high levels of carbonic anhydrase

e. acid secretion is maintained at constant levels by local feedback mechanisms

  • e. acid secretion is maintained at constant levels by local feedback mechanisms

Q. Tissues in which insulin does NOT facilitate glucose uptake?

a. red blood cells

b. skeletal muscle

c. cardiac muscle

d. smooth muscle

e. aorta

  • a. red blood cells

Q. Regarding the “iodide pump” in thyroid cells, which is NOT true?

a. it is stimulated by TSH

b. it depends on Na+ / K+ ATPase activity

c. it pumps iodide into the colloid, after entering the cell down an electrical gradient

d. it pumps iodide against an electrical gradient

e. its activity can be measured with trace doses of radioactive iodine

  • c. it pumps iodide into the colloid, after entering the cell down an electrical gradient

Q. Regarding the control of thyroid secretion:

a. free T3 and T4 exert feedback control on anterior pituitary

b. free T3 and T4 exert feedback control on hypothalamus

c. free T3 and T4 exert feedback control on anterior pituitary and hypothalamus

d. free T3 and T4 do not affect day to day control of their secretion

e. the basal metabolic rate is the most important determinant of thyroid secretion

  • c. free T3 and T4 exert feedback control on anterior pituitary and hypothalamus

Q. The following are true of chylomicrons EXCEPT:

a. they are large lipoprotein complexes

b. they are part of the exogenous lipid transport system

c. they enter the circulation via the lymphatic ducts

d. they are cleared from the circulation by lipoprotein lipase on the surface of hepatocytes

e. chylomicron remnants are bound to LDL R and endocytosed

  • d. they are cleared from the circulation by lipoprotein lipase on the surface of hepatocytes

Q. All of the following are true regarding chylomicrons EXCEPT:

a. they contain triglycerides, cholesterol and phospholipids

b. they are formed in the intestinal mucosa

c. they are cleared from the circulation by lipoprotein lipase

d. they are transported to the liver by the portal circulation

e. large numbers after a meal give the plasma a milky appearance

  • d. they are transported to the liver by the portal circulation

Q. The tissue or organ with the greatest potential for increasing the metabolic rate of thebody is:

a. liver

b. skin

c. adipose tissue

d. skeletal muscle

e. digestive system

  • d. skeletal muscle

Q. Triglycerides are transported to cells via:

a. chylomicron remnants

b. HDL

c. LDL

d. VLDL

e. none of the above

  • d. VLDL

Q. Regarding vitamin B12

a. it is a fat soluble vitamin

b. its absorption is inhibited by trypsin

c. it is mainly carried in plasma by attachment to albumin

d. it undergoes enterohepatic circulation

e. none of the above are true

  • d. it undergoes enterohepatic circulation

Q. Regarding HDL:

a. HDL transports ingested cholesterol from the intestine

b. HDL transports triglycerides from peripheral tissues

c. HDL receptors on macrophages are called scavenger receptors

d. elevated HDL levels are associated with increased risk of atherosclerosis

e. none of the above are correct

  • c. HDL receptors on macrophages are called scavenger receptors

Q. Regarding free fatty acids in plasma, which of the following is NOT true?

a. they account for less than 10% of total fatty acids in plasma

b. they are complexed with a protein carrier

c. they can be metabolised to CO2 and water in skeletal and cardiac muscle

d. their level in plasma decreases as plasma adrenaline increases

e. they are converted to energy by the citric acid cycle

  • d. their level in plasma decreases as plasma adrenaline increases

Q. Ubiquitin is:

a. an essential amino acid

b. a polypeptide that tags proteins for degradation

c. a cell membrane glycoprotein

d. a precursor or uric acid

e. none of the above

  • b. a polypeptide that tags proteins for degradation

Q. In a fasting adult at rest:

a. skeletal muscle metabolises mainly glucose

b. the brain accounts for approximately 40% of glucose utilised

c. blood glucose concentrations are higher in women than in men

d. blood glucose levels are maintained initially by hepatic glycogenolysis

e. ketones are absent from plasma

  • d. blood glucose levels are maintained initially by hepatic glycogenolysis
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