Top 150+ Solved Medicinal Chemistry 1 MCQ Questions Answer
Q. Which of the following is the correct decreasing order of drug metabolism?
a. Liver > lungs > kidneys > intestine > placenta > skin > adrenals
b. Liver > lungs > kidneys > intestine > adrenals > placenta > skin
c. Liver > kidneys > lungs > intestine > placenta > adrenals > skin
d. Liver > lungs > intestine > kidneys > placenta > adrenals > skin
Q. Which one of the following is reactive and a known carcinogenic?
a. Cytochrome P-450
b. Catechol
c. Glutathione
d. Arene oxide
Q. Which of the following is not an example of a drug undergoing acetylation reaction?
a. Hydrazine
b. Salicylic acids
c. Sulphonamides
d. Histamines
Q. The overall rate of biotransformation is higher in neonates and infants than in adults.
a. True
b. False
c. none
d. all
Q. In comparison with children and young adults, elderly adults tend to have a reducedcapacity to metabolize drugs.
a. True
b. False
c. none
d. all
Q. What is enzyme induction?
a. The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals
b. The phenomenon of increasing drug bioavailability drugs and chemicals
c. The phenomenon of increasing drug distribution drugs and chemicals
d. The phenomenon of increasing drug concentration for a particular tissue by drugs and chemicals
Q. Which of the following drugs has self -induction to stimulate their own metabolism?
a. Cortisol
b. Pentobarbital
c. Meprobamate
d. Contraceptives
Q. Alcohol is the inducer for which drug?
a. Cortisol
b. Pentobarbital
c. Meprobamate
d. Oral contraceptives
Q. What is the name of the process where structurally same compounds compete for the same site on an enzyme to inhibit that?
a. Altered physiology
b. Repression
c. Non-competitive inhibition
d. Competitive inhibition
Q. What is the name of the process where structurally different compounds interact with the enzyme and prevent the metabolism of the drug?
a. Altered physiology
b. Repression
c. Non-competitive inhibition
d. Competitive inhibition
Q. What is the name of the process where the enzyme amount is decreases due to a decrease in enzyme synthesis?
a. Altered physiology
b. Repression
c. Non-competitive inhibition
d. Competitive inhibition
Q. What is the name of the process where due to nutritional deficiency an enzyme content isdecreased?
a. Altered physiology
b. Repression
c. Non-competitive inhibition
d. Competitive inhibition
Q. Which one of the following is not an environmental agent to decrease drug metabolizing ability?
a. DDT
b. Cigarette smoke
c. Organophosphate insecticides
d. Methacholine
Q. What is polygenic control of drugs?
a. Drug controlling seen in an individual
b. Drug controlling seen in twins
c. Drug controlling seen in between different species
d. Drug controlling seen in a particular population