Top 150+ Solved Medicinal Chemistry 1 MCQ Questions Answer
Q. Which of the following statements is the closest description of Phase II metabolism?
a. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.
b. Reactions which occur in the blood supply.
c. Reactions which add a polar functional group to a drug.
d. Reactions which occur in the gut wall.
Q. Which of the following is not a characteristic of the moieties that are transferred to the substrate in phase II reactions?
a. Simple endogenous molecules are transferred
b. Large molecular sized groups are attached
c. Strong polar groups are attached
d. Strong nonpolar groups are attached
Q. Which of the following enzymes is not involved in catalyzing Phase I metabolic reaction?
a. Flavin-containing monooxygenases
b. Oxidation of alkyl groups
c. Glucuronyl transferase
d. Esterases
Q. Which of the following reactions is not a Phase I metabolic transformation?
a. Reduction of ketones
b. Conjugation to alcohols
c. Monoamine oxidases
d. Esterhydrolysis
Q. What is the major end product of oxidation of aromatic carbon atoms?
a. Arenols
b. Catechol
c. Glutathione
d. Arene oxide
Q. Which of the following is not a common N containing functional groups which undergoreduction reactions?
a. Nitro compounds
b. Azo compounds
c. N-oxide compounds
d. Nitrite compounds
Q. What does the hydrolysis of Aspirin yield us with?
a. Salicylic acid only
b. Salicylic acid and CH3COOH
c. CH3COOH
d. Succinic acid
Q. Which enzyme is important in the Phase II reactions?
a. Esterase
b. Amidases
c. Transferase
d. Aldo-keto-reductases
Q. Which of the following groups is least susceptible to cytochrome P450 enzymes?
a. Terminal methyl groups
b. Epoxide group
c. Benzylic carbon atoms
d. Quaternary carbon atoms
Q. Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved?
a. cytochrome P450 enzymes
b. epoxide hydrolase
c. both of the above
d. neither of the above
Q. Solubility of a drug in polar solvents and Non-polar solvents depends upon
a. Chemical structure
b. Particle size
c. Crystal form
d. All of above
Q. Higher will be the diffusion of the drug across the membrane if
a. Higher value of partition-coefficient
b. Low value of partition-coefficient
c. Higher water soluble
d. None of above
Q. Diazepam gets metabolised into Hydroxydiazepam is example of
a. Oxidation at allylic carbon atom
b. Oxidation at the carbon alpha to carbonyl and imino group
c. Oxidation at benzylic carbon atom
d. Aromatic and Side chain Hydroxylation
Q. __________reaction is most common in drugs having ester or amide functional groups
a. Oxidative reactions
b. Reduction
c. Hydrolysis
d. Phase I
Q. UDPGA means....
a. Urane diphospho -a- D glucuronic acid
b. Uridine diphospho -a- D glucuronic acid
c. Uridine diphospho-D glucuronic acid
d. Uric diphospho -a- D glucuronic acid