Top 150+ Solved Medicinal Chemistry 1 MCQ Questions Answer
Q. Addition of non-polar group _________ partition co-efficient
a. Improves
b. Reduces
c. No effect on
d. none
Q. Gentamicin, streptokinase can be given
a. Orally
b. Parentrally
c. Both of above
d. None of above
Q. p-nitrophenol contains
a. Intramolecular H-bond
b. Intermolecular H-bond
c. Both of above
d. None of above
Q. Which one of the following factors related to protein-drug binding is not related to drugs?
a. Physicochemical characteristics of a drug
b. The concentration of the drug in the body
c. The affinity of the drug for binding
d. Number of binding sites on the binding agent
Q. Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
a. Competition between the drug and the binding site
b. Competition between drugs and normal body constituents
c. Allosteric changes in a protein molecule
d. Inter subject variation
Q. Which of the following factors for protein drug binding is a drug interaction factor?
a. Competition between drugs for the binding site
b. Age
c. Physicochemical characteristics of a drug
d. Physicochemical characteristics of the protein or binding agent
Q. Plasma proteins bound with drugs by formation of
a. Hydrogen bonding
b. Hydrophobc bonding
c. Vander-waals force
d. All
Q. The most significant protein involved in binding with a drug is
a. Albumin
b. Glycoprotein
c. Lipoprotein
d. Globulin
Q. The most abundant plasma protein is
a. Albumin (HAS – Human serum albumin)
b. Glycoprotein
c. Lipoprotein
d. Globulin
Q. Chelating agent Dimercaprol is used in the treatment of
a. Lead poisoning
b. Vanadium poisoning
c. Arsenic poisoning
d. All of above
Q. In Lead and vanadium poisoning, which chelating agent is used as an antidote?
a. Disodium EDTA
b. Haemoglobin
c. Cyanocobalamine
d. Dimercaprol