Top 150+ Solved Medicinal Chemistry 1 MCQ Questions Answer
Q. Which of the following statement is false?
a. D-glucuronic acid is easily available
b. Several functional groups can be easily linked with the D-glucuronic acid
c. Conjugation with D-glucuronic acid occurs to a high degree
d. Whole animal kingdom have the common ability to produce D-glucuronic acid
Q. Which enzyme is of the utmost importance for the 2nd step in the formation ofGlucuronide?
a. Esterase
b. Amidases
c. Transferase
d. UDP-glucuronyl tr
Q. What is the site of first-pass metabolism before molecules reach systemic circulation?
a. Kidney
b. Throat
c. Liver
d. Intestine
Q. What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme andP-glycoprotein?
a. Kidney
b. Throat
c. Liver
d. Intestine
Q. What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?
a. Ames test
b. Biochemical tests
c. Serology
d. Polymorphisms
Q. Which of the following are protein components of the cytochrome P450 system?
a. Heme protein CYP450
b. NADH-CYP450 reductase
c. NADPH-CYP450 reductase
d. A and B E. A and C
Q. Which of the following statements is not true about cytochrome P450 enzymes?
a. They contain haem and magnesium.
b. They belong to a general class of enzymes called monooxygenases.
c. There are over 30 different cytochrome P450 enzymes.
d. Variation in cytochrome P450 enzyme profile between individuals can explain individual variation in drug susceptibility.
Q. What cytochrome P450 isozyme is most abundantly expressed in the human liver andintestines?
a. CYP1A1
b. CYP3A4
c. CYP2C9
d. CYP2D6
Q. Which of the following is an antiarrhythmic drug that is a calcium channel blocker?
a. Lidocaine
b. Nitroglycerin
c. Nifedipine
d. Codeine
Q. What drug should not be given to a patient that is a poor CYP2D6 metabolizer?
a. Codeine
b. Lidocaine
c. Nifedipine
d. Nitroglycerin
Q. What injection is administered directly into systemic circulation causing rapiddistribution?
a. Intramuscular
b. Intravenous
c. Intracerebral
d. Intraspinal
Q. What are xenobiotics?
a. Another form of antibiotics
b. A form of nutrient
c. Nutrients which kill the gut harmful microbes
d. Anything that is not nutrients and enters the body through different routes
Q. What is the active form of salicylic acid?
a. Sialic acid
b. Salic acid
c. Salicylic acid
d. Salicycle acid