Top 550+ Solved Physiology MCQ Questions Answer

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Q. Regarding the O2 dissociation curve:

a. increased PCO2 has a direct effect on the curve, shifting it to the right

b. 2,3-DPG levels rise as altitude

c. the deoxy form of Hb is in the relaxed state

d. CO moves the curve to the left as it has 100 times the affinity of O2 for Hb

e. P50 is at a PO2 of 40mmHg

  • b. 2,3-DPG levels rise as altitude

Q. Which respiratory principle is INCORRECT?

a. Fick’s law states that “the volume of gas per unit time that moves across a sheet of tissue is proportional to the area of the sheet, but inversely proportional to its thickness”

b. the Bohr effect is “the effect of PCO2 on the O2 dissociation curve due to the action of PCO2 on H+ concentration”

c. Henry’s law states that “the amount of gas dissolved is proportional to the partial pressure of that gas”

d. the chloride shift is “the diffusion of HCO3 - in to the cell, with the outward diffusion of Cl- ions to maintain electrical neutrality”

e. the Haldane effect is that deoxygenation of the blood increases its ability to carry CO2

  • d. the chloride shift is “the diffusion of HCO3 - in to the cell, with the outward diffusion of Cl- ions to maintain electrical neutrality”

Q. Given a PCO2 = 600mmHg and a HCO3- = 28mEq/l there is a:

a. metabolic acidosis

b. metabolic acidosis with renal compensation

c. respiratory acidosis

d. respiratory acidosis with renal compensation

e. respiratory alkalosis

  • c. respiratory acidosis

Q. Regarding the elastic properties of the lung:

a. the lung volume at any given pressure during inflation is larger than during deflation

b. the area under the pressure-volume curve is known as the compliance

c. surface tension is the force acting across an imaginary line in the surface of the liquid

d. pressure generated in an alveolus equals 4T/R

e. surfactant, produced by Type I alveolar cells, reduces surface tension in alveoli

  • c. surface tension is the force acting across an imaginary line in the surface of the liquid

Q. Halving the radius of an airway increases resistance:

a. 2-fold

b. 4-fold

c. 8-fold

d. 16-fold

e. has no effect on resistance

  • d. 16-fold

Q. The major site of resistance in the bronchial tree is the:

a. segmental bronchii

b. medium-sized bronchii

c. small bronchii

d. large bronchioles

e. terminal bronchioles

  • b. medium-sized bronchii

Q. Lung compliance increases with:

a. asthma

b. alveolar oedema

c. pulmonary hypertension

d. atelectasis

e. pulmonary fibrosis

  • a. asthma

Q. The ventilatory response to CO2 is increased by:

a. sleep

b. increasing age

c. trained athlete

d. morphine

e. decreased PO2

  • e. decreased PO2

Q. Normally the FEV1 is what percentage of FVC?

a. 50%

b. 60%

c. 70%

d. 80%

e. 90%

  • d. 80%

Q. The calibre of extra-alveolar vessels is primarily determined by:

a. the difference between alveolar pressure and the pressure within them

b. the pressure in the pulmonary artery

c. the lung volume

d. the cardiac output

e. the patient’s fluid status

  • c. the lung volume

Q. Which statement regarding hyperbaric oxygen therapy is INCORRECT?

a. males eliminate carboxy haemoglobin faster than females

b. gas around the body is normal air compressed to the same high pressure

c. it produces marked increases in dissolved oxygen in the blood

d. oxygen is administered at up to 3 atmospheres pressure

e. toxicity includes optic neuritis

  • a. males eliminate carboxy haemoglobin faster than females

Q. All of the following are features of acclimatisation to high altitude EXCEPT:

a. shift to the right of the oxygen dissociation curve

b. increased number of capillaries in peripheral tissues

c. pulmonary vasodilation

d. polycythaemia

e. increased maximum breathing capacity

  • c. pulmonary vasodilation

Q. Which of the following statements is TRUE?

a. pulmonary stretch receptors lie within the airway epithelial cells

b. J receptors, when stimulated, cause slow deep breathing

c. irritant receptors, when stimulated, send impulses up the vagus in unmyelinated fibres

d. irritant receptors are rapidly adapting

e. increased maximum breathing capacity

  • d. irritant receptors are rapidly adapting

Q. Which one of the following statements regarding ventilation is INCORRECT?

a. tidal volume in the average human is 500ml

b. anatomical dead space is the volume of the conducting airway and is about 160ml

c. upper regions of the lung ventilate better than the lower regions

d. you can measure physiological dead space via Bohr’s method to get what is called a Bohr equation which is: VD PACO2-PECO2 VT PACO2

e. None of the above

  • c. upper regions of the lung ventilate better than the lower regions

Q. The diffusion capacity (DI) of the lung accounts for:

a. P1-P2

b. area of lung

c. the thickness

d. diffusion constant

e. all of the above

  • a. P1-P2
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