Top 150+ Solved Pathology MCQ Questions Answer
Q. Infective endocarditis
a. in the acute form, is most commonly caused by streptococci
b. involves abnormal valves in most acute cases
c. is confirmed by positive blood cultures in less than 50% of cases
d. may cause splenic infarction
e. may cause MacCallum’s plaques to form on affected valves
Q. Cor Pulmonale may be caused by
a. congenital heart disease
b. mitral stenosis
c. left ventricular failure
d. primary pulmonary hypertension
e. aortic regurgitation
Q. Regarding peptic ulceration
a. it occurs most commonly in the antrum of the stomach
b. it has a strong genetic influence
c. there is H. pylori infection of the mucosa in 50% of patients with duodenal ulceration
d. it is more frequent in patients with chronic obstructive pulmonary disease
e. gastric acid is the only prerequisite for formation of ulcers
Q. The features of bronchogenic carcinoma include
a. the classification of “oat cell” tumour within the large cell type
b. high initial response to chemotherapy for small cell type
c. the strongest correlation with cigarette smoking in the adenocarcinoma type
d. that 50% of small cell type occur in nonsmokers
e. histological features identical in small cell carcinomas and squamous cell types
Q. The major abnormalities of immune function in AIDS are characterised by
a. Inversion of the CD4-CD8 ratio
b. Increase in the number of memory T cells
c. Hypogammaglobulinaemia and decreased circulating immune complexes
d. Decreased secretion of TNF and IL-1
e. All of the above
Q. Regarding hypersensitivity reactions
a. In anaphylaxis, IgE is bound to mast cells by their Fab portions to release vasoactive amines
b. Goodpasture’s syndrome is an example of type III hypersensitivity reaction
c. Farmer’s lung is a type III reaction to micropolyspora species
d. Delayed hypersensitivity is mediated by macrophages
e. The Mantoux reaction is a form of contact hypersensitivity
Q. Acute appendicitis
a. In preschool children, it usually presents with the so-called “classic” signs and symptoms
b. It is associated with appendiceal obstruction in 10% of cases
c. Histologically, it shows neutrophilic infiltration of the muscularis layer
d. The clinical diagnosis is falsely positive in about 50% of cases
e. It cannot cause liver abscesses
Q. Pneumocystis carinii
a. Produces pneumocystis pneumonia in normal persons
b. Causes a Ghon’s focus in the lung
c. Causes patchy atelectasis
d. Is a fungus
e. Attaches selectively to Type II alveolar cells
Q. Regarding septic shock
a. Endotoxin is the only cause
b. Marked vasoconstriction occurs in the non-infected tissue
c. Cardiac output is low in 75% of patients
d. Endotoxin entering the circulation causes an effect very similar to anaphylaxis
e. Blood viscosity is unchanged
Q. Acute pancreatitis
a. Is associated with increased serum amylase concentration without elevation in serum lipase concentration
b. Occurs most often in later life
c. Occurs in about 5% of patients with gallstones
d. When associated with alcohol is not usually preceded by chronic pancreatitis
e. Is often associated with hypercalcaemia
Q. The acute nephritic syndrome has all of the following features except
a. Proteinuria
b. Haematuria
c. Hypertension
d. Hyaline casts
e. Oliguria
Q. A young baby presents with jaundice, dark urine and pale stools. He is most likely to have
a. Physiologic jaundice of the newborn
b. Breast milk jaundice
c. Gilbert’s syndrome
d. Biliary atresia
e. None of the above
Q. With regard to the leukocyte extravasation of the acute inflammatory response, which of the following is incorrect
a. ELAM-1 is a selectin found on endothelium
b. E and P-selectins bind to oligosaccharides found on neutrophils and monocytes
c. L-selectin is found on neutrophils, monocytes and lymphocytes
d. ICAM-1 belongs to the immunoglobulin family of molecules, and is found on leukocytes
e. VCAM-1 binds to integrins
Q. IgE mediated Type I hypersensitivity reactions require the action of which lymphocyte class
a. B only
b. CD8 T cells and B cells
c. Tµ2 T cells and B cells
d. Tµ1 T cells and B cells
e. Natural Killer cells and B cells
Q. Thrombus formation is inhibited by
a. Von Willebrands factor
b. IL-1
c. Alpha 2 macroglobulin
d. TNF
e. Endothelial cell injury