Top 150+ Solved Pathology MCQ Questions Answer

From 76 to 90 of 135

Q. The immediate lethal dose of radiation exposure for humans in a non-mass casualty situation is

a. 50 rads

b. 150 rads

c. 250 rads

d. 350 rads

e. 450 rads

  • e. 450 rads

Q. With regard to apoptosis, which of the following is incorrect

a. it may be regarded as a normal physiological process

b. it is characterised by chromatin condensation

c. it often elicits a strong inflammatory response

d. it is the process by which ovaries atrophy in post menopausal women

e. it is characterised by cell shrinkage

  • c. it often elicits a strong inflammatory response

Q. With regard to the acute inflammatory response, which is the most common mechanism of vascular leakage

a. endothelial cell contraction

b. junctional retraction

c. direct injury

d. leukocyte-dependent leakage

e. regenerating endothelium

  • a. endothelial cell contraction

Q. With regard to cellular injury, all of the following are reversible except

a. decreased ATP

b. intracellular release of lysosomal enzymes

c. decreased Na pump activity

d. detachment of ribosomes

e. ER swelling

  • b. intracellular release of lysosomal enzymes

Q. With regard to the role of complement in the acute inflammatory response, which of thefollowing is incorrect

a. C5a is a powerful, chemotactic agent for neutrophils, monocytes and eosinophils

b. C5a increases leukocyte adhesion to endothelium by activating leukocytes

c. C3a and C5a are called anaphylatoxins because they cause mast cell degranulation

d. C3a activates the lipoxygenase pathway in leukocytes

e. C3 and C5 can be activated in inflammatory exudate by lysosomal enzymes

  • d. C3a activates the lipoxygenase pathway in leukocytes

Q. Coagulative necrosis

a. results from necrosis in which cellular enzymatic digestion predominates over denaturation

b. is characterised by a marked leukocytic infiltrate

c. is uncommon after myocardial infarction

d. usually occurs after irreversible ischaemic cellular damage

e. is not usually seen in association with caseous necrosis

  • d. usually occurs after irreversible ischaemic cellular damage

Q. Granulomatous inflammation

a. may sometimes be a component of the acute inflammatory response

b. indicates the presence of tuberculosis

c. consists, in part, of microscopic aggregates of transformed lymphocytes

d. is always associated with the presence of giant cells

e. may result from non-immune mechanisms

  • e. may result from non-immune mechanisms

Q. Removal of sutures from a wound at day 7 coincides with a wound strength of

a. 1% of unwounded skin strength

b. 10% of unwounded skin strength

c. 50% of unwounded skin strength

d. 75% of unwounded skin strength

e. 100%, i same as unwounded skin

  • b. 10% of unwounded skin strength

Q. In a healthy individual over the age of 5 years, lymphocytes are mainly found in

a. bone marrow, thymus, spleen

b. liver, thymus, spleen

c. lymph nodes, spleen, thymus

d. bone marrow, spleen, liver

e. liver, spleen, pancreas

  • c. lymph nodes, spleen, thymus

Q. With regard to natural killer lymphocytes

a. constitute less than 5% of blood lymphocytes

b. require opsonisation to enable their killing of cells

c. have a prime role in defense against parasites

d. require prior sensitisation to be effective

e. have an innate ability to lyse tumour cells and virally affected cells

  • e. have an innate ability to lyse tumour cells and virally affected cells

Q. With regard to B lymphocytes

a. they constitute 50% of circulating lymphocytes

b. they are found in germinal centres in the red pulp of the spleen

c. they are genetically programmed to recognise specific antigens by means of antigen specific cell surface receptors

d. they release chemical mediators when attached to IgE Type I hypersensitivity reactions

e. they are not affected by HIV infection

  • c. they are genetically programmed to recognise specific antigens by means of antigen specific cell surface receptors

Q. Transplant rejection involves

a. Type IV hypersensitivity only

b. Type IV and III hypersensitivity only

c. Type IV, III and II hypersensitivity only

d. Type IV and II hypersensitivity only

e. Type II and III hypersensitivity only

  • c. Type IV, III and II hypersensitivity only

Q. Successful immune response to HIV during the acute phase of infection results from

a. increase in the CD4+ lymphocyte numbers

b. appearance of anti-HIV antibodies

c. Type III hypersensitivity reaction

d. lymphoid tissue based destruction of infected cells

e. development of CD8+ virus specific cytotoxic cells

  • e. development of CD8+ virus specific cytotoxic cells

Q. With respect to macrophages, which of the following is not true

a. they can produce TNF and IL4 both of which cause fever

b. they have direct tissue toxicity due to the ability to release hydrogen peroxide

c. they have oxygen dependent microbicidal activity

d. they have cytotoxicity against tumour cells

e. they process antigens and act as antigen presenting cells to activate lymphocytes

  • a. they can produce TNF and IL4 both of which cause fever

Q. In viral hepatitis

a. the majority of cases of acute Hepatitis B infection result in a carrier state, without clinical evidence of disease

b. anti HB s appears in the first week of infection

c. anti HCV IgG does not confer immunity to Hepatitis C

d. the major cause of death from Hepatitis B is hepatocellular carcinoma

e. Hepatitis A virus has an outer surface envelope of protein, lipid and carbohydrate

  • c. anti HCV IgG does not confer immunity to Hepatitis C
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