Q. Why is NSAIDs use a relative contraindication in patients with chronic renal failure? (Solved)
1. direct toxic effects on proximal tubule
2. direct toxic effects on collecting ducts
3. indirect toxic effects on loop of Henle
4. inhibition of prostaglandin synthesis which is an important regulator of renal blood flow in arterioles
5. inhibition of prostaglandin synthesis which is an important regulator of renal blood flow in main renal arteries
- d. inhibition of prostaglandin synthesis which is an important regulator of renal blood flow in arterioles