Top 550+ Solved Physiology MCQ Questions Answer

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Q. A sarcomere:

a. contains two separate halves of an A-band and an I-band

b. is the space between two A-bands

c. is between two Z-lines

d. has the T-system of the sarcotubular system at sarcomere junctions

e. contracts when the troponin molecule binds to the myosin head

  • c. is between two Z-lines

Q. Type I muscle fibres:

a. have fast glycolytic rates

b. have low oxidative capacity

c. are more commonly found in muscle that performs explosive work

d. do not have a very high glycolytic capacity

e. are not abundant in endurance athletes

  • d. do not have a very high glycolytic capacity

Q. Regarding cardiac muscle, which statement is INCORRECT?

a. resting membrane potential is about -90mV

b. energy source at rest is mainly fat

c. mechanical response lasts about twice as long as electrical response

d. tetanus cannot occur

e. it has an all-or-nothing contractile response

  • c. mechanical response lasts about twice as long as electrical response

Q. Regarding denervation:

a. it causes skeletal muscle hypertrophy

b. does not lead to fibrillation

c. causes hyposensitivity to acetylcholine in skeletal muscle

d. smooth muscle is able to contract if it occurs in vivo

e. causes fasciculations

  • d. smooth muscle is able to contract if it occurs in vivo

Q. Which of the following nerve fibre types is MOST sensitive to pressure?

a. A-beta

b. A-gamma

c. A-delta

d. B

e. C

  • a. A-beta

Q. Which of the following nerve fibre types has the LARGEST diameter?

a. C

b. A-alpha

c. B

d. A-gamma

e. A-beta

  • b. A-alpha

Q. The following are NOT energy sources of muscle:

a. phosphorylcreatine

b. fatty acids

c. glucose

d. glycogen

e. creatine

  • e. creatine

Q. Regarding sensory organ stimulation, which statement is INCORRECT?

a. adaptation occurs over the temperature range 20-40°C

b. pain is sensed by naked nerve endings

c. pacinian corpuscles are rapidly adapting touch-pressure receptors

d. naked nerve endings can detect all four cutaneous sensory modalities

e. any given nerve ending can signal more than one sensory modality

  • e. any given nerve ending can signal more than one sensory modality

Q. Regarding neurotransmitters, which of the following is INCORRECT?

a. glutamate is excitatory

b. GABA is inhibitory at presynaptic neurons

c. glycine is excitatory at postsynaptic neurons

d. GHB (gamma hydroxybutyrate) is inhibitory

e. aspartate is excitatory

  • c. glycine is excitatory at postsynaptic neurons

Q. The stretch reflex:

a. is classically initiated by tapping on the quadriceps muscle

b. is initiated by stretch of the muscle

c. involves impulses being conducted from the muscle spindle to the motor cortex

d. involves extrafusal fibres stimulating annulospiral and flowerspray sensory fibres

e. involves gamma afferents of leksell

  • b. is initiated by stretch of the muscle

Q. Which of the following is NOT present in smooth muscle cells?

a. actin

b. myosin-II

c. tropomyosin

d. almodulin

e. troponin

  • e. troponin

Q. Regarding the structure of cardiac muscle, which statement is INCORRECT?

a. T-system lies at Z-lines

b. functions as a syncytium due to the presence of tight junctions

c. intercalated discs occur at Z-lines

d. contains large numbers of elongated mitochondria

e. thin filaments include troponin T, C and I

  • b. functions as a syncytium due to the presence of tight junctions

Q. Regarding the cardiac muscle action potential, which statement is INCORRECT?

a. sodium ions enter via “fast” channels in phase 0

b. chloride ions may enter cell during phase 1

c. sodium ions enter via “slow” channels in phase 2

d. relative refractory period ends in phase 3

e. class I anti-arrhythmics reduce the slope of phase 4

  • a. sodium ions enter via “fast” channels in phase 0

Q. Regarding neuromuscular transmission, which statement is INCORRECT?

a. smooth muscle cells possess synapses en passant

b. about 10 times as much acetylcholine as is required is released at skeletal muscle neuromuscular junctions

c. antibodies can develop to calcium channels in nerve endings at neuromuscular junctions

d. more than one nerve fibre ends on each end-plate in skeletal muscle

e. acetylcholine is released by exocytosis

  • d. more than one nerve fibre ends on each end-plate in skeletal muscle
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