Top 80+ Solved Drug Metabolism MCQ Questions Answer
Q. What cytochrome P450 isozyme is most abundantly expressed in the human liver andintestines?
a. CYP1A1
b. CYP3A4
c. CYP2C9
d. CYP2D6
Q. Which of the following is an antiarrhythmic drug that is a calcium channel blocker?
a. Lidocaine
b. Nitroglycerin
c. Nifedipine
d. Codeine
Q. What drug should not be given to a patient that is a poor CYP2D6 metabolizer?
a. Codeine
b. Lidocaine
c. Nifedipine
d. Nitroglycerin
Q. What injection is administered directly into systemic circulation causing rapiddistribution?
a. Intramuscular
b. Intravenous
c. Intracerebral
d. Intraspinal
Q. What are xenobiotics?
a. Another form of antibiotics
b. A form of nutrient
c. Nutrients which kill the gut harmful microbes
d. Anything that is not nutrients and enters the body through different routes
Q. What is the active form of salicylic acid?
a. Sialic acid
b. Salic acid
c. Salicylic acid
d. Salicycle acid
Q. Which of the following is the correct decreasing order of drug metabolism?
a. Liver > lungs > kidneys > intestine > placenta > skin > adrenals
b. Liver > lungs > kidneys > intestine > adrenals > placenta > skin
c. Liver > kidneys > lungs > intestine > placenta > adrenals > skin
d. Liver > lungs > intestine > kidneys > placenta > adrenals > skin
Q. Which one of the following is reactive and a known carcinogenic?
a. Cytochrome P-450
b. Catechol
c. Glutathione
d. Arene oxide
Q. Which of the following is not an example of a drug undergoing acetylation reaction?
a. Hydrazine
b. Salicylic acids
c. Sulphonamides
d. Histamines
Q. The overall rate of biotransformation is higher in neonates and infants than in adults.
a. True
b. False
c. none
d. all
Q. In comparison with children and young adults, elderly adults tend to have a reducedcapacity to metabolize drugs.
a. True
b. False
c. none
d. all
Q. What is enzyme induction?
a. The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals
b. The phenomenon of increasing drug bioavailability drugs and chemicals
c. The phenomenon of increasing drug distribution drugs and chemicals
d. The phenomenon of increasing drug concentration for a particular tissue by drugs and chemicals
Q. Which of the following drugs has self -induction to stimulate their own metabolism?
a. Cortisol
b. Pentobarbital
c. Meprobamate
d. Contraceptives