Top 80+ Solved Drug Metabolism MCQ Questions Answer
Q. Biotransformation of drugs is defined as the conversion from one physical form toanother.
a. True
b. False
c. none
d. all
Q. Following are the Phase I reactions except ____________
a. Oxidative reactions
b. Hydrolytic reactions
c. Reductive reactions
d. Sulphide reactions
Q. Which of the following statements is the closest description of Phase I metabolism?
a. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites
b. Reactions which occur in the blood supply.
c. Reactions which add a polar functional group to a drug.
d. Reactions which occur in the gut wall.
Q. Which of the following statements is the closest description of Phase II metabolism?
a. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.
b. Reactions which occur in the blood supply.
c. Reactions which add a polar functional group to a drug.
d. Reactions which occur in the gut wall.
Q. Which of the following is not a characteristic of the moieties that are transferred to the substrate in phase II reactions?
a. Simple endogenous molecules are transferred
b. Large molecular sized groups are attached
c. Strong polar groups are attached
d. Strong nonpolar groups are attached
Q. Which of the following enzymes is not involved in catalyzing Phase I metabolic reaction?
a. Flavin-containing monooxygenases
b. Oxidation of alkyl groups
c. Glucuronyl transferase
d. Esterases
Q. Which of the following reactions is not a Phase I metabolic transformation?
a. Reduction of ketones
b. Conjugation to alcohols
c. Monoamine oxidases
d. Esterhydrolysis
Q. What is the major end product of oxidation of aromatic carbon atoms?
a. Arenols
b. Catechol
c. Glutathione
d. Arene oxide
Q. Which of the following is not a common N containing functional groups which undergoreduction reactions?
a. Nitro compounds
b. Azo compounds
c. N-oxide compounds
d. Nitrite compounds
Q. What does the hydrolysis of Aspirin yield us with?
a. Salicylic acid only
b. Salicylic acid and CH3COOH
c. CH3COOH
d. Succinic acid
Q. Which enzyme is important in the Phase II reactions?
a. Esterase
b. Amidases
c. Transferase
d. Aldo-keto-reductases