Top 80+ Solved Drug Metabolism MCQ Questions Answer
Q. Which of the following groups is least susceptible to cytochrome P450 enzymes?
a. Terminal methyl groups
b. Epoxide group
c. Benzylic carbon atoms
d. Quaternary carbon atoms
Q. Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved?
a. cytochrome P450 enzymes
b. epoxide hydrolase
c. both of the above
d. neither of the above
Q. Solubility of a drug in polar solvents and Non-polar solvents depends upon
a. Chemical structure
b. Particle size
c. Crystal form
d. All of above
Q. Higher will be the diffusion of the drug across the membrane if
a. Higher value of partition-coefficient
b. Low value of partition-coefficient
c. Higher water soluble
d. None of above
Q. Diazepam gets metabolised into Hydroxydiazepam is example of
a. Oxidation at allylic carbon atom
b. Oxidation at the carbon alpha to carbonyl and imino group
c. Oxidation at benzylic carbon atom
d. Aromatic and Side chain Hydroxylation
Q. __________reaction is most common in drugs having ester or amide functional groups
a. Oxidative reactions
b. Reduction
c. Hydrolysis
d. Phase I
Q. UDPGA means....
a. Urane diphospho -a- D glucuronic acid
b. Uridine diphospho -a- D glucuronic acid
c. Uridine diphospho-D glucuronic acid
d. Uric diphospho -a- D glucuronic acid
Q. Which of the following statement is false?
a. D-glucuronic acid is easily available
b. Several functional groups can be easily linked with the D-glucuronic acid
c. Conjugation with D-glucuronic acid occurs to a high degree
d. Whole animal kingdom have the common ability to produce D-glucuronic acid
Q. Which enzyme is of the utmost importance for the 2nd step in the formation ofGlucuronide?
a. Esterase
b. Amidases
c. Transferase
d. UDP-glucuronyl tr
Q. What is the site of first-pass metabolism before molecules reach systemic circulation?
a. Kidney
b. Throat
c. Liver
d. Intestine
Q. What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme andP-glycoprotein?
a. Kidney
b. Throat
c. Liver
d. Intestine
Q. What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?
a. Ames test
b. Biochemical tests
c. Serology
d. Polymorphisms
Q. Which of the following are protein components of the cytochrome P450 system?
a. Heme protein CYP450
b. NADH-CYP450 reductase
c. NADPH-CYP450 reductase
d. A and B E. A and C
Q. Which of the following statements is not true about cytochrome P450 enzymes?
a. They contain haem and magnesium.
b. They belong to a general class of enzymes called monooxygenases.
c. There are over 30 different cytochrome P450 enzymes.
d. Variation in cytochrome P450 enzyme profile between individuals can explain individual variation in drug susceptibility.