Top 50+ Solved CNS Drugs MCQ Questions Answer

a. Fluoxetine

b. Amitriptylline

c. Moclobemide

d. Ondansetron

e. Sumatriptan

a. Morphine

b. Pethidine

c. Methadone

d. Fentanyl

e. Codeine

a. Is lipid soluble

b. Is metabolised by the MEOS system at blood concentrations below 100mg/dl

c. Is a vasodilator

d. The most frequent neurological abnormality in chronic alcoholism is asymmetrical peripheral nerve injury specific to hands and feet

e. Alcohol is estimated to be responsible for approximately 10% of cases of hypertension

a. Bupivacaine

b. Ropivacaine

c. Prilocaine

d. Procaine

e. Lignocaine

a. It produces inactive metabolites

b. It induces enzymes only to a minimal extent

c. It causes less hangover than nitrazepam

d. It causes rebound insomnia

e. It increases REM sleep

a. Lorazepam has documented efficacy against absence seizures

b. Phenytoin is able to stimulate its own metabolism by enzyme induction

c. Valproate has a large Vd (>500l/70kg)

d. The most common dose related adverse effects of Carbamazepine are ataxia and diplopia

e. Vigabatrin works by sodium channel blockade

a. Bromocriptine is the first line drug to treat Parkinson’s disease in psychotic patients

b. 80-90% of a single dose of Levodopa enters the brain unaltered

c. Patients taking Selesiline to treat Parkinson’s disease are limited in what they can eat because of the tyranine reaction phenomenon

d. Amantadine has anti Parkinsonian effects and is administered at a dose of 100mg bd

e. Anti muscarinic drugs are of benefit in elimination of bradykinesia in Parkinson’s

a. Suxamethonium

b. Propofol

c. Isoflurane

d. Atracurium

e. Ketamine

a. Has rapid onset of action

b. Is partially renally excreted

c. Has no neurological side effects

d. Has no contraindications to be given in conjunction with NSAIDS

e. Is contraindicated in sick sinus syndrome

a. Fentanyl works predominantly at the kappa receptors

b. Both U and delta receptors contribute to respiratory depression

c. Methadone is used for heroin withdrawal because its actions are predominantly at the delta receptors

d. Opioid receptors are coupled to a tyrosine kinase mechanism of action

e. Physical dependence and tolerance is caused by the rapid disintegration of receptors

a. Penetrates the axon in its changed form

b. Is more potent than bupivacaine

c. Has higher affinity for activated than resting sodium channels

d. Is a weak acid

e. Blocks voltage gated sodium channels at their extracellular end

a. Post op vomiting is common

b. Hypertension is a complication

c. Severe acidosis can occur with its use in paediatric respiratory infections

d. It is positively inotropic

e. Tremor is a common side effect

a. They reduce MAP in direct proportion to their alveolar concentration

b. Nitrous oxide has a relatively low MAC

c. Halogenated agents have a lower brain:blood partition coefficient

d. Nitrous oxide causes a decrease in tidal volume and an increase in respiratory rate

e. They decrease the metabolic rate in the brain by decreasing cerebral blood flow

a. Are primarily K+ channel blockers

b. Prevent repolarisation of the membrane

c. Can be used with a vasodilator to prolong local action

d. Activity is enhanced by high extracellular K+ concentration

e. Activity is enhanced by high extracellular Ca2+

a. Phenytoin – gum hypertrophy

b. Ethosuximide – hirsuitism

c. Phenobarbital – enzyme induction

d. Carbamazepine – ataxia

e. Valproate – idiosyncratic hepatic toxicity